Table 3.
Associations between microbial genera abundance and bone measures in the MrOS cohorts.
| MrOS Cohort Microbial Genera – Bone Associations, FDR=0.1 | |||||
|---|---|---|---|---|---|
| Genera | Phenotype | Beta | Stderr | P-val | Q-val |
| Cortical Bone Measures | |||||
| Methanobrevibacter | t_Ct_vBMD | -0.304 | 0.097 | 1.70E-03 | 5.44E-02 |
| DTU089 | t_Ct_vBMD | -0.211 | 0.070 | 2.49E-03 | 6.84E-02 |
| Lachnospiraceae NK4A136 group | t_Ct_vBMD | 0.246 | 0.081 | 2.61E-03 | 6.87E-02 |
| Trabecular Bone Measures | |||||
| Cloacibacillus | t_Tb_Inn_vBMD | 0.201 | 0.069 | 3.85E-03 | 9.64E-02 |
| Cloacibacillus | t_Tb_vBMD | 0.202 | 0.069 | 3.66E-03 | 9.14E-02 |
Bone measures were collected using high resolution peripheral quantitative computed tomography. Taxa-bone associations with Benjamini & Hochberg false discovery rate (FDR) adjusted P-value (Q-value) ≤0.1 are shown because there were no associations with Q-value ≤ 0.05. Skeletal phenotypes are grouped according to whether they were measured in cortical bone, trabecular bone, or whole bone, or overall measures of skeletal strength. All associations were adjusted for covariates.