TABLE 2.

Values of pharmacokinetic parameters for GS 4071 following i.v. administration of GS 4071 or oral administration of GS 4104 to animals^a

Species	Compound	Dose (mg-eq/kg), route of administration	AUC0–24 (mg · h/liter)	Cmax (μg/ml)	Tmax (h)	CL (liters/h/kg)	t1/2 (h)	VSS (liters/kg)	F (%)
Mouse (n = 3)	GS 4071	10, i.v.	13			0.77	NDb	3.9
	GS 4104	10, oral	3.9	1.2	1.0		ND		30
Rat (n = 4)	GS 4071	10, i.v.	8.4			1.5	1.6	1.3
	GS 4104	10, oral	3.0	0.47	1.6		7.0		35
Ferret (n = 3)	GS 4071	1, i.v.	2.2			0.33	0.6	0.28
	GS 4104	5, oral	1.2	0.20	2.0		5.7		11
Dog (n = 5)	GS 4071	5, i.v.	18			0.32	1.8	0.56
	GS 4104	5, oral	11	1.2	3.8		3.7		73

^aValues are means and are based on the levels of GS 4071 in plasma. 

^bND, not determined.