Table 5.
Modified Poisson regression analyses (risk ratios) for associations between maternal delivery and venous cord Se biomarkers and adverse birth outcomes
(95 % confidence intervals)
| Outcome | Se biomarker* | Timepoint | n | Unadjusted risk ratio | 95 % CI | P | n | Adjusted risk ratio† | 95 % CI | P |
|---|---|---|---|---|---|---|---|---|---|---|
| Small-for-gestational age | WBSe | Delivery | 445 | 1·03 | 0·96, 1·1 | 0·4 | 416 | 1·04 | 0·96, 1·1 | 0·3 |
| WBSe | Venous cord | 441 | 1·06 | 0·99, 1·1 | 0·07 | 411 | 1·07 | 1·0, 1·1 | 0·05 | |
| Serum Se | Delivery | 496 | 1·02 | 0·9, 1·1 | 0·7 | 486 | 1·05 | 0·9, 1·2 | 0·4 | |
| SEPP1 | Delivery | 650 | 0·99 | 0·85, 1·2 | 0·9 | 643 | 1·03 | 0·9, 1·2 | 0·7 | |
| SEPP1 | Venous cord | 555 | 0·8 | 0·6, 1·0 | 0·08 | 527 | 0·7 | 0·5, 0·9 | 0·01 | |
| Low birth weight | WBSe | Delivery | 445 | 1·05 | 0·95, 1·2 | 0·3 | 416 | 1·12 | 1·0, 1·3 | 0·04 |
| WBSe | Venous cord | 441 | 1·11 | 1·0, 1·2 | 0·02 | 411 | 1·08 | 0·99, 1·2 | 0·1 | |
| Serum Se | Delivery | 496 | 1·06 | 0·93, 1·2 | 0·4 | 486 | 1·12 | 0·97, 1·3 | 0·1 | |
| SEPP1 | Delivery | 650 | 0·99 | 0·85, 1·2 | 0·9 | 643 | 1·2 | 1·0, 1·5 | 0·1 | |
| SEPP1 | Venous cord | 555 | 0·8 | 0·6, 1·0 | 0·08 | 527 | 0·9 | 0·6, 1·3 | 0·5 | |
| Preterm birth | WBSe | Delivery | 467 | 1·01 | 0·8, 1·2 | 0·9 | 418 | 1·31 | 0·9, 1·9 | 0·2 |
| WBSe | Venous cord | 448 | 1·13 | 0·96, 1·3 | 0·2 | 413 | 1·01 | 0·8, 1·3 | 0·9 | |
| Serum Se | Delivery | 517 | 1·11 | 0·9, 1·4 | 0·3 | 487 | 0·99 | 0·7, 1·4 | 0·9 | |
| SEPP1 | Delivery | 677 | 0·95 | 0·7, 1·3 | 0·8 | 644 | 1·06 | 0·67, 1·7 | 0·8 | |
| SEPP1 | Venous cord | 562 | 0·5 | 0·26, 1·0 | 0·06 | 529 | 1·2 | 0·5, 3·0 | 0·7 |
WBSe, whole blood selenium; SEPP1, selenoprotein P.
WBSe scaled to represent the change in anthropometric outcome for every 10 µg/l increase in WBSe. Serum Se scaled to represent the change in anthropometric outcome for every 10 µg/l increase in serum Se. SEPP1 scaled to represent the change in anthropometric outcome for every 1000 µg/l increase in SEPP1.
Models adjusted for infant sex, season of birth, maternal age, maternal education, maternal height, maternal BMI, gravidity, vitamin D treatment group, delivery CRP, asset index quintiles, daily protein intake (kg), smoking and tobacco use during pregnancy.