FIG. 1.

Metabolism of bisbenzamidoximes (compound 1, 3, 5, or 7) by rat liver homogenate 9,000 × g supernatant fraction. Homogenates containing 167 μM diamidoxime as substrate plus cofactor solution were incubated for 30 min at 37°C, then assayed by HPLC as described in Materials and Methods. Compound structures are shown in Table 1. IS, internal standard.