TABLE 2.
Correlation between the IFIT1/3 LIs in OSCC samples and clinicopathological parameters of OSCC patients.
| Clinical parameters | Mean IFIT1 LI ± SD (%) | p‐Value | Mean IFIT3 LI ± SD (%) | p‐Value |
|---|---|---|---|---|
| Patients' age (year) | ||||
| ≤50 (n = 19) | 55 ± 30 | 0.838 | 68 ± 26 | 0.795 |
| >50 (n = 21) | 60 ± 23 | 75 ± 16 | ||
| Patients' sex | ||||
| Female (n = 7) | 57 ± 24 | 0.470 | 63 ± 21 | 0.260 |
| Male (n = 33) | 64 ± 22 | 72 ± 18 | ||
| Cancer location | ||||
| Buccal mucosa (n = 20) | 64 ± 21 | 0.952 | 63 ± 24 | 0.089 |
| Tongue (n = 13) | 69 ± 26 | 79 ± 18 | ||
| Other sites (n = 7) | 54 ± 20 | 72 ± 6 | ||
| T classification | ||||
| T1 + T2 (n = 23) | 43 ± 30 | <0.001* | 58 ± 28 | <0.001* |
| T3 + T4 (n = 17) | 87 ± 10 | 87 ± 16 | ||
| N classification | ||||
| N0 (n = 22) | 56 ± 27 | 0.014* | 61 ± 27 | 0.010* |
| N1 + N2 + N3 (n = 18) | 75 ± 22 | 83 ± 23 | ||
| Clinical staging | ||||
| Stage1 + 2 (n = 11) | 43 ± 26 | <0.001* | 55 ± 29 | 0.005* |
| Stage3 + 4 (n = 29) | 78 ± 21 | 80 ± 21 | ||
| Histology of OSCC | ||||
| Well differentiated (n = 29) | 56 ± 20 | 0.509 | 68 ± 22 | 0.447 |
| Moderately and poorly differentiated (n = 11) | 61 ± 18 | 74 ± 17 | ||
| Oral habits | ||||
| Alcohol drinking | ||||
| Without (n = 10) | 54 ± 19 | 0.440 | 66 ± 20 | 0.203 |
| With (n = 30) | 61 ± 21 | 75 ± 17 | ||
| Areca nut chewing | ||||
| Without (n = 9) | 43 ± 24 | 0.012* | 56 ± 23 | 0.025* |
| With (n = 31) | 69 ± 25 | 76 ± 21 | ||
| Cigarette smoking | ||||
| Without (n = 8) | 54 ± 16 | 0.483 | 68 ± 20 | 0.391 |
| With (n = 32) | 61 ± 21 | 74 ± 17 | ||
Abbreviations: LIs, labeling indices; OSCC, oral squamous cell carcinoma.
*
Statistical significance (p < 0.05).