TABLE 2.
Effectiveness of early antibiotic treatment in mice with pneumonic plaguea
| Antibiotic | No. of survivors/total (%) | Pb |
|---|---|---|
| Streptomycin | 20/20 (100) | |
| Netilmicin | 20/20 (100) | 1.000 |
| Gentamicin | ||
| 12 mg/kg | 32/40 (80) | 0.043 |
| 20 mg/kg | 16/20 (80) | 0.016 |
| Ciprofloxacin | 35/35 (100) | 1.000 |
| Ofloxacin | 20/20 (100) | 1.000 |
| Cefazolin | 5/20 (25) | <0.00001 |
| Cefotetan | 14/20 (70) | 0.002 |
| Ceftriaxone | 20/20 (100) | 1.000 |
| Ceftazidime | 17/20 (85) | 0.231 |
| Ceftizoxime | 11/20 (55) | 0.00123 |
| Aztreonam | 17/20 (85) | 0.231 |
| Ampicillin | 17/20 (85) | 0.231 |
| Rifampin | 18/20 (90) | 0.487 |
a
Treatment was initiated 24 h after aerosol infection of Hsd:ND4 mice with 100 ± 50 LD50s of Y. pestis CO92.
b
Values obtained by Fisher’s exact two-tailed test comparing survival of various antibiotic treatment groups to survival with streptomycin.