TABLE 3.
Effectiveness of late antibiotic treatment in mice with pneumonic plaguea
| Antibiotic | No. of survivors/total (%) | Pb |
|---|---|---|
| Streptomycin | 50/85 (59) | |
| Netilmicin | 24/40 (60) | 1.000 |
| Gentamicin | ||
| 12 mg/kg | 12/38 (32) | 0.006 |
| 20 mg/kg | 17/20 (85) | 0.038 |
| Ciprofloxacin | 28/45 (62) | 0.851 |
| Ofloxacin | 12/20 (60) | 1.000 |
| Cefazolin | 2/18 (11) | 0.00021 |
| Cefotetan | 0/19 (0) | <0.00001 |
| Ceftriaxone | 1/40 (2.5) | <0.00001 |
| Ceftazidime | 0/20 (0) | <0.00001 |
| Aztreonam | 0/19 (0) | <0.00001 |
| Ampicillin | 1/19 (5) | 0.000016 |
| Rifampin | 4/20 (20) | 0.0024 |
a
Treatment was initiated 42 h after aerosol infection of Hsd:ND4 mice with 100 ± 50 LD50s of Y. pestis CO92.
b
Values obtained by Fisher’s exact two-tailed test comparing survival of various antibiotic treatment groups to survival with streptomycin.