TABLE 4.
Effectiveness of ceftriaxone versus streptomycin for the treatment of experimental plague infection following subcutaneous injection
| Antibiotic | Time to start of treatment (h postchallenge)a | No. of survivors/total (%) | Time to death (h postchallenge)b | Pc |
|---|---|---|---|---|
| Streptomycin | 24 | 20/20 (100) | ||
| 42 | 14/20 (70) | 296 ± 19.5 | ||
| 48 | 5/20 (25) | 209 ± 24.4 | ||
| 54 | 9/20 (45) | 226 ± 25.8 | ||
| Ceftriaxone | 24 | 14/20 (70) | 272 ± 25.4 | 0.0086 |
| 42 | 0/20 (0) | 152 ± 8.7 | <0.00001 | |
| 48 | 0/20 (0) | 110 ± 9.1 | 0.0005 | |
| 54 | 0/20 (0) | 119 ± 11.8 | 0.0006 | |
| NS | 24 | 0/10 (0) | 65 ± 3.7 | <0.0001 |
| 48 | 0/20 (0) | 72 ± 2.8 | <0.0001 |
a
Treatment after subcutaneous infection of Hsd:ND4 mice with 1.0 × 104 to 1.5 × 104 LD50s of Y. pestis CO92.
b
Values are means ± standard errors.
c
Values obtained by Fisher’s exact two-tailed test comparing survival of various antibiotic treatment groups to survival with streptomycin initiated at the same time postinfection.