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Correlation of heme polymerase IC50 and accumulation-normalized absolute drug IC50 (calculated for isolates 3D7 and K1 by normalizing the CAR for each drug studied to that for the drug with the highest CAR for each isolate). These normalized levels of drug accumulation have then been multiplied by the corresponding absolute IC50 of each compound for isolates 3D7 (r = 0.81; P = 0.026) (A) and K1 (r = 0.17; P = 0.72) (B).
