TABLE 1.

IC₅₀s for heme polymerization and antimalarial drug potencies

Drug	IC50 (μM) for heme polymerization	Antimalarial drug potency (IC50 [nM] at an inoculum size of 1)
		3D7	HB3	K1	PH3
AQ	15.1	7.8	8.5	18.5	13.8
CQ	24.4	14.0	18.5	192.1	158.8
DesAQ	42.8	6.9	6.5	38.8	33.4
BidesAQ	72.9	21.3	18.6	166.0	119.8
DesCQ	44.8	18.9	18.3	718.5	645.1
BidesCQ	58.3	55.3	47.2	1,338.6	1,256.3
AMOPYR	29.5	5.3	4.7	11.5	9.8
PYR	64.4	5.7	6.2	9.1	10.1
MEP	41.0	12.9	17.8	43.3	32.6
TBQ	52.7	9.5	8.2	13.1	11.6
4-deOH TBQ	50.6	42.1	57.2	69.3	75.2
4F-TBQ	40.5	60.7	53.7	68.7	61.3
NTB-AQ	31.6	5.5	4.8	9.1	10.5
CQ-PYROL	43.6	19.5	17.3	89.6	76.3
AQ-PYRID	72.5	682.3	794.1	1,337.5	1,298.0
CQ-PYRID	91.6	11,660.5	10,224.5	15,119.4	14,612.3
De-SC-AQ	19.0	1,398.1	1,546.8	2,264.7	2,139.3
QN	64.8	34.2	36.8	81.2	74.3
QND	24.0	21.5	23.9	50.6	43.6
CIN	22.6	20.6	26.7	56.2	40.5
CIND	27.2	40.1	35.1	90.6	75.4
HF	184.5	5.8	5.2	2.8	3.2
MQ	46.9	23.4	18.2	9.4	11.2
ARM	>1,000	2.3	1.6	1.2	2.2
ART	>1,000	4.3	3.4	5.8	4.2
DHA	>1,000	0.1	0.3	0.2	0.4
PQ	>1,000	NDa	ND	ND	ND

^aND, not determined.