TABLE 2.
Absolute antimalarial drug potencies and CARs derived from inoculum effect analysis and accumulation-normalized absolute IC50s of drugsa
| Drug | Absolute antimalarial drug potency (IC50 [nM])
|
CAR
|
Accumulation-normalized IC50 of the drug (arbitrary units)
|
|||
|---|---|---|---|---|---|---|
| 3D7 | K1 | 3D7 | K1 | 3D7 | K1 | |
| AQ | 2.4 | 16.8 | 8,955 | 3,653 | 0.27 | 4.18 |
| CQ | 5.8 | 83.6 | 5,768 | 1,346 | 0.42 | 7.66 |
| DesAQ | 3.26 | 36.9 | 19,250 | 3,758 | 0.79 | 9.44 |
| NTB-AQ | 1.67 | 7.21 | 47,171 | 14,694 | 0.99 | 7.21 |
| AMOPYR | 0.84 | 4.57 | 48,173 | 12,994 | 0.51 | 4.04 |
| TBQ | 1.22 | 4.3 | 79,456 | 14,584 | 1.22 | 4.27 |
| 4F-TBQ | 49.4 | 65.4 | 905 | 1,495 | 0.56 | 6.65 |
a
The accumulation-normalized absolute IC50s of various drugs (for isolates 3D7 and K1) were calculated by normalizing the CAR for each drug studied to that for the drug with the highest CAR for each isolate. These normalized levels of drug accumulation have then been multiplied by the corresponding absolute IC50 of each compound.