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. 2023 Sep 18;55(3):309–316. doi: 10.3947/ic.2023.0084

Table 3. Summary of reported cases of granulomatous Pneumocystis Jirovecii pneumonia (PCP) in solid organ transplanted patients.

Year Age/Sex SOT Granulomatous PCP onset after transplantation Immunosuppressant Symptoms Radiological findings PCP PCR Confirmation Hypercalcemia Reference
1975 F/37 KT 7 months, rejection, no prophylaxis Azathioprine, prednisone Fever, yellow sputum Patchy interstitial infiltration Not done Open lung biopsy, non-caseating epithelioid-cell granuloma, GMS+ Not described [30]
2014 F/54 KT 2 years Prednisolone, tacrolimus, MMF Dry cough, fever Ground glass opacities Positive Transbronchial biopsy granulomatous with exudates, GMS + Yes [22]
2019 M/53 KT 13 years, no rejection Prednisolone, cyclosporine, MMF Fatigue, dyspnea Diffuse patchy ground glass and reticular opacities Negative Transbronchial biopsy, Granulomatous infiltration and giant cells, GMS + Yes [27]
Present case M/60 KT 24 years, rejection Tacrolimus, sirolimus, deflazacort Sore throat Multiple nodules Positive Open lung biopsy, Granuloma with necrosis, GMS + No

SOT, solid organ transplant; PCR, polymerase chain reaction; bronchoalveolar lavage; F, female; KT, kidney transplantation; GMS, Gomori methenamine silver stain; M, male; MMF, mycophenolic acid.