Table 3. Summary of reported cases of granulomatous Pneumocystis Jirovecii pneumonia (PCP) in solid organ transplanted patients.
Year | Age/Sex | SOT | Granulomatous PCP onset after transplantation | Immunosuppressant | Symptoms | Radiological findings | PCP PCR | Confirmation | Hypercalcemia | Reference |
---|---|---|---|---|---|---|---|---|---|---|
1975 | F/37 | KT | 7 months, rejection, no prophylaxis | Azathioprine, prednisone | Fever, yellow sputum | Patchy interstitial infiltration | Not done | Open lung biopsy, non-caseating epithelioid-cell granuloma, GMS+ | Not described | [30] |
2014 | F/54 | KT | 2 years | Prednisolone, tacrolimus, MMF | Dry cough, fever | Ground glass opacities | Positive | Transbronchial biopsy granulomatous with exudates, GMS + | Yes | [22] |
2019 | M/53 | KT | 13 years, no rejection | Prednisolone, cyclosporine, MMF | Fatigue, dyspnea | Diffuse patchy ground glass and reticular opacities | Negative | Transbronchial biopsy, Granulomatous infiltration and giant cells, GMS + | Yes | [27] |
Present case | M/60 | KT | 24 years, rejection | Tacrolimus, sirolimus, deflazacort | Sore throat | Multiple nodules | Positive | Open lung biopsy, Granuloma with necrosis, GMS + | No |
SOT, solid organ transplant; PCR, polymerase chain reaction; bronchoalveolar lavage; F, female; KT, kidney transplantation; GMS, Gomori methenamine silver stain; M, male; MMF, mycophenolic acid.