TABLE 1.
Pharmacokinetic parameters for intravenous PMPA in male beagle dogsa
| PMPA dose (mg/kg) | AUC0–∞ (μg · h/ml) | C0 (μg/ml) | MRT (h) | CL (ml/h/kg) | VSS (ml/kg) | Terminal t1/2 (h) | % Dose recovered in urine at 48 h |
|---|---|---|---|---|---|---|---|
| 1.0 | 2.87 (0.40) | 3.27 (0.27) | 2.62 (0.94) | 353 (47.2) | 899 (238) | 4.51 (1.94) | 84.3 (4.53) |
| 10.0 | 36.7 (7.94) | 33.1 (6.39) | 6.21 (0.75) | 281 (51.3) | 1,740 (329) | 9.54 (1.21) | 50.6 (12.5) |
a
Values are means (SDs) for five animals. Abbreviations: C0, concentration extrapolated to zero time; MRT, mean residence time; CL, clearance; VSS, volume of distribution at steady state; t1/2, half-life.