Table 1. Participant Demographic and Presenting Characteristics, Medical History, and Medications.
| Characteristic | Participants, No. (%) | P value | ||||
|---|---|---|---|---|---|---|
| All (n = 10 678) | Enteric-coated aspirin | Uncoated aspirin | ||||
| 81 mg (n = 4074) | 325 mg (n = 3292) | 81 mg (n = 1300) | 325 mg (n = 2012) | |||
| Age, median (IQR), y | 68.0 (61.3-73.7) | 68.4 (61.8-73.8) | 68.2 (61.7-73.8) | 67.1 (60.1-73.2) | 67.2 (60.6-73.4) | <.001 |
| Sex | ||||||
| Male | 7285 (68.2) | 2827 (69.4) | 2235 (67.9) | 863 (66.4) | 1360 (67.6) | .16 |
| Female | 3393 (31.8) | 1247 (30.6) | 1057 (32.1) | 437 (33.6) | 652 (32.4) | |
| History of PAD | 2436 (23.4) | 916 (23.0) | 736 (22.9) | 298 (23.7) | 486 (24.7) | .46 |
| Race | ||||||
| Black or African American | 900 (8.4) | 335 (8.2) | 257 (7.8) | 147 (11.3) | 161 (8.0) | .003 |
| White | 8965 (84.0) | 3432 (84.2) | 2786 (84.6) | 1040 (80.0) | 1707 (84.8) | |
| Othera | 482 (4.5) | 195 (4.8) | 136 (4.1) | 68 (5.2) | 83 (4.1) | |
| Prefer not to say/missing | 331 (3.1) | 112 (2.7) | 113 (3.4) | 45 (3.5) | 61 (3.0) | |
| Ethnicity | ||||||
| Hispanic | 270 (2.5) | 101 (2.5) | 80 (2.4) | 42 (3.2) | 47 (2.3) | .39 |
| Non-Hispanic | 10 051 (94.2) | 3850 (94.5) | 3104 (94.3) | 1204 (92.8) | 1893 (94.1) | |
| Did not respond | 354 (3.3) | 123 (3.0) | 108 (3.3) | 51 (3.9) | 72 (3.6) | |
| Current smoker | 1006 (9.4) | 368 (9.0) | 272 (8.3) | 144 (11.1) | 222 (11.0) | .001 |
| Baseline P2Y12 inhibitor use | 2300 (22.0) | 880 (22.0) | 707 (22.0) | 294 (23.1) | 419 (21.3) | .68 |
| EHR and claims information | ||||||
| Weight | ||||||
| No. | 9313 | 3572 | 2879 | 1125 | 1737 | .02 |
| Median (IQR), kg | 90.0 (78.2-103.6) | 90.0 (78.6-103.6) | 89.5 (77.3-103.6) | 90.0 (77.7-103.2) | 91.4 (79.5-105.9) | |
| Height | ||||||
| No. | 9172 | 3532 | 2838 | 1104 | 1698 | .41 |
| Median (IQR), cm | 172.7 (165.1-180.3) | 172.7 (165.1-180.3) | 172.7 (165.1-180.3) | 172.7 (165.1-180.3) | 172.7 (165.1-180.3) | |
| BMI | ||||||
| No. | 9074 | 3486 | 2807 | 1097 | 1684 | .01 |
| Median (IQR) | 30.0 (26.7-34.2) | 30.1 (26.7-34.2) | 29.9 (26.5-34.0) | 29.9 (26.6-34.2) | 30.3 (27.0-34.8) | |
| Atrial fibrillation or flutter | 884 (8.5) | 325 (8.2) | 286 (8.9) | 101 (8.0) | 172 (8.7) | .64 |
| History of bleedingb | 894 (8.6) | 290 (7.3) | 305 (9.5) | 129 (10.3) | 170 (8.6) | <.001 |
| Significant GI tract bleed | 661 (6.3) | 222 (5.6) | 224 (7.0) | 97 (7.7) | 118 (6.0) | .01 |
| History of ICH | 155 (1.5) | 50 (1.3) | 55 (1.7) | 16 (1.3) | 34 (1.7) | .30 |
| History of bleeding disorder | 126 (1.2) | 35 (0.9) | 38 (1.2) | 24 (1.9) | 29 (1.5) | .02 |
| Prior CABG | 2525 (24.2) | 989 (24.9) | 774 (24.1) | 291 (23.2) | 471 (23.9) | .63 |
| Coronary artery disease | 9763 (93.7) | 3730 (93.7) | 3036 (94.5) | 1165 (92.8) | 1832 (93.0) | .07 |
| CHF | 2392 (23.0) | 902 (22.7) | 744 (23.2) | 282 (22.5) | 464 (23.6) | .84 |
| Chronic kidney disease | 1835 (17.6) | 718 (18.0) | 547 (17.0) | 217 (17.3) | 353 (17.9) | .69 |
| COPD | 1938 (18.6) | 724 (18.2) | 605 (18.8) | 235 (18.7) | 374 (19.0) | .86 |
| CVD | 1880 (18.0) | 713 (17.9) | 566 (17.6) | 231 (18.4) | 370 (18.8) | .74 |
| Diabetes | 3988 (38.3) | 1472 (37.0) | 1224 (38.1) | 517 (41.2) | 775 (39.3) | .04 |
| Hypertension | 8873 (85.2) | 3413 (85.8) | 2734 (85.1) | 1060 (84.5) | 1666 (84.6) | .53 |
| Hyperlipidemia | 9232 (88.6) | 3547 (89.1) | 2879 (89.6) | 1088 (86.7) | 1718 (87.2) | .005 |
| Prior MI | 3739 (35.9) | 1403 (35.3) | 1144 (35.6) | 473 (37.7) | 719 (36.5) | .41 |
| Peptic ulcer disease | 312 (3.0) | 120 (3.0) | 91 (2.8) | 39 (3.1) | 62 (3.1) | .92 |
| PCI or CABG | 5648 (54.2) | 2183 (54.9) | 1728 (53.8) | 682 (54.3) | 1055 (53.6) | .74 |
| Prior aspirin use | 10 275 (96.2) | 3932 (96.5) | 3195 (97.1) | 1231 (94.7) | 1917 (95.3) | <.001 |
| Prior aspirin dose | ||||||
| 81 mg | 8714 (84.8) | 3344 (85.0) | 2781 (87.0) | 1014 (82.4) | 1575 (82.2) | <.001 |
| 162 mg | 250 (2.4) | 102 (2.6) | 77 (2.4) | 30 (2.4) | 41 (2.1) | |
| 325 mg | 1295 (12.6) | 481 (12.2) | 334 (10.5) | 184 (14.9) | 296 (15.4) | |
| Other | 16 (0.2) | 5 (0.1) | 3 (0.1) | 3 (0.2) | 5 (0.3) | |
| ARM use | 3904 (37.3) | 1528 (38.2) | 1239 (38.5) | 440 (34.6) | 697 (35.4) | .01 |
Abbreviations: ARM, acid reducing medication; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CABG, coronary artery bypass graft; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; EHR, electronic health record; GI, gastrointestinal; ICH, intracerebral hemorrhage; MI, myocardial infarction; PAD, peripheral artery disease; PCI, percutaneous coronary intervention.
a
Other includes Asian, American Indian or Alaska Native, multiple race, or other.
b
History of bleeding includes GI tract bleed, ICH, and bleeding disorder.