Table 2.
Adjusted 12-month health status outcomes in invasively managed and revascularized patients.
| Baseline Angina | None N=521 |
Monthly N=740 |
Daily/Weekly N=378 |
Interaction P-value |
|---|---|---|---|---|
| Effect of anatomic CR vs ICR | ||||
| SAQ-7 Angina Frequency Score | 1.55 (0.85, 2.83) | 1.04 (0.71, 1.53) | 2.15 (1.31, 3.53) | 0.04 |
| SAQ-7 Summary Score | 1.15 (0.79, 1.67) | 0.90 (0.67, 1.20) | 1.60 (1.05, 2.44) | 0.05 |
| Quality of Life | 0.99 (0.66, 1.48) | 0.78 (0.57, 1.07) | 1.39 (0.90, 2.16) | 0.06 |
| Physical Function | 1.03 (0.64, 1.65) | 1.08 (0.76, 1.53) | 1.72 (1.07, 2.76) | 0.18 |
| Rose Dyspnea Score | 1.28 (0.80, 2.06) | 1.21 (0.84, 1.72) | 1.79 (1.11, 2.89) | 0.35 |
| EQ-5D | 1.19 (0.83, 1.71) | 0.89 (0.66, 1.19) | 1.37 (0.90, 2.07) | 0.15 |
| Effect of functional CR vs ICR | ||||
| SAQ-7 Angina Frequency Score | 1.15 (0.64, 2.04) | 1.14 (0.77, 1.67) | 2.06 (1.23, 3.45) | 0.11 |
| SAQ-7 Summary Score | 1.13 (0.78, 1.63) | 1.17 (0.86, 1.58) | 1.54 (1.03, 2.32) | 0.43 |
| Quality of Life | 1.08 (0.73, 1.58) | 1.09 (0.79, 1.49) | 1.43 (0.94, 2.17) | 0.48 |
| Physical Function | 1.03 (0.66, 1.60) | 1.32 (0.90, 1.93) | 1.48 (0.93, 2.35) | 0.48 |
| Rose Dyspnea Score | 1.25 (0.80, 1.95) | 1.21 (0.85, 1.74) | 1.63 (0.99, 2.70) | 0.57 |
| EQ-5D | 0.95 (0.67, 1.34) | 1.00 (0.75, 1.35) | 1.48 (0.99, 2.21) | 0.17 |
| Degree of Ischemia |
None-Mild
N=160 |
Moderate
N=575 |
Severe
N=906 |
|
| Effect of anatomic CR vs ICR | ||||
| SAQ-7 Angina Frequency Score | 0.96 (0.46, 2.01) | 1.64 (1.04, 2.59) | 1.31 (0.88, 1.96) | 0.43 |
| SAQ-7 Summary Score | 0.98 (0.52, 1.82) | 1.51 (1.06, 2.15) | 0.90 (0.68, 1.19) | 0.04 |
| Quality of Life | 0.99 (0.52, 1.87) | 1.07 (0.74, 1.56) | 0.92 (0.68, 1.23) | 0.77 |
| Physical Function | 0.99 (0.47, 2.09) | 1.73 (1.14, 2.61) | 0.97 (0.69, 1.36) | 0.07 |
| Rose Dyspnea Score | 1.79 (0.90, 3.55) | 1.38 (0.91, 2.10) | 1.21 (0.85, 1.70) | 0.55 |
| EQ-5D | 1.52 (0.83, 2.79) | 1.15 (0.81, 1.62) | 0.98 (0.74, 1.30) | 0.35 |
| Effect of functional CR vs ICR | ||||
| SAQ-7 Summary Score | 1.22 (0.62, 2.43) | 1.66 (1.18, 2.33) | 1.03 (0.78, 1.35) | 0.07 |
| SAQ-7 Angina Frequency Score | 1.13 (0.50, 2.57) | 1.47 (0.94, 2.29) | 1.28 (0.87, 1.89) | 0.81 |
| Quality of Life | 1.10 (0.54, 2.22) | 1.27 (0.88, 1.81) | 1.14 (0.85, 1.52) | 0.87 |
| Physical Function | 1.43 (0.66, 3.07) | 1.85 (1.24, 2.76) | 0.96 (0.68, 1.35) | 0.02 |
| Rose Dyspnea Score | 2.32 (1.07, 5.02) | 1.25 (0.84, 1.85) | 1.28 (0.90, 1.81) | 0.33 |
| EQ-5D | 1.37 (0.71, 2.65) | 1.12 (0.81, 1.55) | 1.02 (0.77, 1.34) | 0.68 |
| Number of CTOs |
0
N=976 |
1
N=560 |
≥2
N=105 |
|
| Effect of anatomic CR vs ICR | ||||
| SAQ-7 Angina Frequency Score | 1.22 (0.85, 1.76) | 1.83 (1.10, 3.04) | 1.16 (0.32, 4.26) | 0.38 |
| SAQ-7 Summary Score | 1.01 (0.76, 1.34) | 1.34 (0.93, 1.91) | 0.58 (0.23, 1.49) | 0.17 |
| Quality of Life | 0.90 (0.67, 1.21) | 1.19 (0.81, 1.75) | 0.84 (0.31, 2.25) | 0.45 |
| Physical Function | 1.17 (0.83, 1.62) | 1.42 (0.90, 2.23) | 0.48 (0.17, 1.37) | 0.17 |
| Rose Dyspnea Score | 1.20 (0.84, 1.70) | 1.63 (1.04, 2.54) | 0.78 (0.24, 2.58) | 0.34 |
| EQ-5D Visual Analog Scale | 0.94 (0.72, 1.23) | 1.37 (0.97, 1.95) | 0.91 (0.30, 2.74) | 0.19 |
| Effect of functional CR vs ICR | ||||
| SAQ-7 Angina Frequency Score | 1.05 (0.71, 1.54) | 1.81 (1.15, 2.85) | 1.77 (0.48, 6.54) | 0.16 |
| SAQ-7 Summary Score | 1.10 (0.82, 1.47) | 1.49 (1.07, 2.07) | 0.91 (0.38, 2.14) | 0.28 |
| Quality of Life | 1.06 (0.78, 1.42) | 1.42 (1.01, 1.99) | 1.12 (0.46, 2.69) | 0.40 |
| Physical Function | 1.21 (0.86, 1.70) | 1.58 (1.06, 2.38) | 0.56 (0.20, 1.55) | 0.15 |
| Rose Dyspnea Score | 1.08 (0.76, 1.53) | 1.82 (1.23, 2.71) | 1.14 (0.39, 3.35) | 0.12 |
| EQ-5D Visual Analog Scale | 0.87 (0.65, 1.16) | 1.43 (1.05, 1.95) | 1.11 (0.44, 2.81) | 0.06 |
CR = complete revascularization; ICR = incomplete revascularization. SAQ=Seattle Angina Questionniare. EQ-5D = EuroQoL 5 Dimensions. Data are presented as odds ratio of likelihood of improvement with complete revascularization compared with incomplete revascularization. Results were adjusted for the following covariates: baseline health status score, age, sex, geographic region, hypertension, diabetes, smoking status, prior MI, heart failure, cerebrovascular disease/prior stroke, peripheral arterial disease, prior PCI, left ventricular ejection fraction, body mass index (BMI), glomerular filtration rate (GFR), New York Heart Association (NYHA) class, stress imaging modality, degree of ischemia on stress test, number of diseased vessels, Duke jeopardy score, SYNTAX score, number of chronic total occlusion (CTO) lesions, presence of calcification or tortuosity, use of intravascular ultrasound (IVUS), fractional flow reserve (FFR), total number of anatomic and ischemic lesions, left main disease, proximal left anterior descending artery (LAD) disease, and the initial mode of revascularization (PCI or CABG).