Table 3.
Demographic and cognitive/functional outcome measure for preliminary sample of completed Phase 2 cases
| NC (n = 20) | MCI (n = 23) | Dementia (n = 9) | p | |
|---|---|---|---|---|
| Demographic Measures | ||||
| Age | 76.65 (3.2) | 80.65 (3.1) | 80.67 (4.4) | ns |
| Sex (% Female) | 45 | 43 | 44 | ns |
| Education | 14.75 (2.3) | 13.78 (1.9) | 14.00 (2.3) | ns |
| TICS-m Hearing Issue (% yes) | 45% | 26% | 56% | ns |
| Neuropsychological Measures | ||||
| TICS-m | 26.25 (1.65)a | 25.57 (2.54)a | 21.56 (5.25)b | 0.001 |
| MoCA | 23.90 (2.92)a | 20.65 (2.82)b | 18.00 (3.32)c | < 0.001 |
| Craft Immediate – Verbatim | 20.25 (4.64)a | 14.04 (6.88)b | 11.67 (6.87)b | 0.001 |
| Craft Delay – Verbatim | 16.85 (5.17)a | 10.35 (6.24)b | 7.33 (6.86)b | < 0.001 |
| Benson Figure Copy | 15.25 (1.21) | 14.65 (2.37) | 13.89 (1.83) | ns |
| Benson Figure Delay Recall | 10.90 (2.65)a | 5.96 (4.13)b | 2.78 (2.95)c | < 0.001 |
| RAVLT A1-A5 Learning Trials (sum) | 31.25 (7.33)a | 23.65 (6.66)b | 23.56 (6.46)b | 0.001 |
| RAVLT A6 Immediate Recall | 5.65 (2.60)a | 2.48 (1.93)b | 0.67 (0.87)c | < 0.001 |
| RAVLT A7 Delay Recall | 4.85 (2.76)a | 1.43 (1.56)b | 0.67 (1.00)b | < 0.001 |
| Number Span Forward – Total Score | 7.20 (2.51) | 6.48 (2.23) | 5.56 (1.88) | ns |
| Number Span Backward – Total Score | 5.40 (1.90)a | 4.96 (1.80)a | 3.33 (1.32)b | 0.019 |
| Category Fluency (Animals+Vegetables) | 29.90 (6.15)a | 25.61 (7.48)a,b | 21.89 (10.14)b | 0.027 |
| Letter Fluency (F + C+L) | 32.60 (8.28) | 35.48 (14.28) | 24.11 (9.28) | ns |
| Digit Symbol (seconds) | 37.40 (7.65)a | 30.30 (9.85)b | 26.11 (9.44)b | 0.005 |
| Multilingual Naming Test | 29.15 (2.25) | 28.30 (2.82) | 28.00 (2.74) | ns |
| Trail Making Test – Part A (s) | 42.20 (13.52)a | 59.87 (28.42)b | 67.56 (23.25)c | 0.011 |
| Trail Making Test – Part B (s) | 117.06 (35.71)a | 220.09 (85.61)b | 222.50 (63.55)b | < 0.001 |
| Clinical and Self-Report Measures | ||||
| CDR-SoB | 0.30 (0.50) a | 0.89 (1.05) a | 3.28 (2.48) b | < 0.001 |
| FAS | 0.60 (1.50) a | 0.59 (1.14) a | 6.33 (4.39) b | < 0.001 |
| IQ-CODE (informant) | 3.17 (0.20) a | 3.16 (0.27) a | 3.54 (0.32) b | < 0.001 |
| IQ-CODE (self) | 3.20 (0.22) a | 3.02 (0.43) a | 3.54 (0.34) b | 0.001 |
| GDS-15 | 2.28 (0.54)a | 1.57 (1.63)a | 2.50 (2.62)a | ns |
Means within a row (i.e., diagnostic groups) without a common superscript letter differ from one another (p < 0.05), as analyzed by one-way ANOVA. Those with the same superscript letter do not significantly differ from one another. TICS-m, Telephone Interview of Cognitive Status – modified; MoCA, Montreal Cognitive Assessment; CDR-SoB, Clinical Dementia Rating Scale–Sum of Boxes; FAS, Functional Activities Scale; IQ-CODE, Informant Questionnaire of Cognitive Decline in the Elderly; GDS-15, Geriatrics Depression Scale – 15 item sub-scale; RAVLT, Rey Auditory Verbal Learning Test; ns, not significant.