Table 2.
Hierarchical linear regression models predicting late life immediate and delayed recall memory by MHT use (Model 1) and diabetes status (Model 2)
| Immediate Recall | Delayed Recall | |||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| Unstandardized | Standardized | Unstandardized | Standardized | Unstandardized | Standardized | Unstandardized | Standardized | |
| B (95% CI) | B | B (95% CI) | B | B (95% CI) | B | B (95% CI) | B | |
| Constant | 16.05 (10.74, 21.36) | 15.87 (10.56, 21.17) | 12.59 (5.77, 19.41) | 12.17 (5.36, 18.98) | ||||
| Word List Version | −0.250 (−0.377,−0.122) | −0.088*** | −0.246 (−0.373,−0.119) | −0.087*** | −0.212 (−0.375, −0.048) | −0.059* | −0.216 (−0.379, −0.053) | −0.060** |
| Age At Assessment (y) | −0.155 (−0.229,−0.082) | −0.097*** | −0.153 (−0.226,−0.079) | −0.095*** | −0.139 (−0.233.−0.044) | −0.068** | −0.133 (−0.228,−0.039) | −0.066** |
| Education (y) | 0.080 (0.049, 0.110) | 0.120 *** | 0.077 (0.046, 0.108) | 0.116 *** | 0.106 (0.066, 0.145) | 0.126 *** | 0.105 (0.066, 0.145) | 0.125 *** |
| APOE4 Carrier (positive) | −0.241 (−0.386, −0.095) | −0.074** | −0.253,−0.399,−0.107) | −0.078*** | −0.352 (−0.539,−0.165) | −0.086*** | −0.532 (−0.539,−0.165) | −0.086*** |
| mCES-D | −0.012 (−0.017, −0.007) | −0.118*** | −0.012 (−0.017, −0.007) | −0.119 *** | −0.008 (−0.014, −0.002) | −0.060* | −0.008 (−0.014, −0.002) | −0.061* |
| Midlife Obesity (BMI <35) | 0.050 (−0.172, 0.273) | 0.010 | 0.119 (−0.108,0.346) | 0.024 | −0.094 (−0.380, 0.192) | −0.015 | −0.018 (−0.309, 0.274) | −0.003 |
| Surgical Menopause | 0.034 (−0.155,0.223) | 0.008 | 0.044 (−0.145, 0.234) | 0.011 | 0.134 (−0.108, 0.377) | 0.025 | 0.085 (−0.193, 0.363) | −0.003 |
| MHT Use History | 0.183 (0.052, 0.314) | 0.063 ** | 0.154 (0.023, 0.286) | 0.053 * | 0.045 (−0.123,0.213) | 0.012 | 0.014 (−0.155, 0.183) | 0.004 |
| Diabetes | −0.320 (−0.524,−0.115) | −0.074** | −0.443 (−0.706,−0.180) | −0.081*** | ||||
| Hyperlipidemia | 0.154 (0.020, 0.289) | 0.054 * | 0.010 (−0.163, 0.183) | 0.003 | ||||
| Hypertension | −0.030 (−0.166, 0.106) | −0.010 | 0.098 (−0.077, 0.273) | 0.027 | ||||
| Heart Disease | 0.007 (−0.165, 0.179) | 0.002 | 0.048 (−0.173, 0.269) | 0.010 | ||||
| Lifetime Smoking Years | 0.001 (−0.003, 0.004) | 0.010 | 0.004 (−0.001, 0.008) | 0.037 | ||||
***
p < 0.001;
**
p < 0.01;
*
p < 0.05;
mCES-D, modified Center for Epidemiological Studies Depression Inventory Score; MHT, menopausal hormone therapy; BMI, body mass index.