Table 3.
Sensitivity analysis among MHT users only (n = 1,088) to assess whether additional MHT or reproduction related factors account for additional variance in late life memory performance
| Immediate Recall | Delayed Recall | |||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| Unstandardized | Standardized | Unstandardized | Standardized | Unstandardized | Standardized | Unstandardized | Standardized | |
| B (95% CI) | B | B (95% CI) | B | B (95% CI) | B | B (95% CI) | B | |
| Constant | 14.55 (8.93–20.17) | 10.92 (4.99, 16.85)] | 3.98 (−4.32, 11.28) | 3.62 (−4.18, 11.41) | ||||
| Word List Version | −0.263 (−0.403,−0.123) | −0.094*** | −0.259 (−0.399,−0.120) | −0.093*** | −0.239 (−0.422, −0.055) | −0.067* | −0.236 (−0.419,−0.053) | −0.066* |
| Age at Assessment (y) | −0.088 (−0.169,−0.006) | −0.056* | −0.091 (−0.173,−0.010) | −0.058* | −0.013 (−0.119, 0.094) | −0.006 | −0.016 (−0.122, 0.091) | −0.008 |
| Education (y) | 0.013 (−0.023, 0.048) | 0.020 | 0.008 (−0.028, 0.044) | 0.013 | 0.026 (−0.021 (0.073) | 0.032 | 0.027 (−0.020, 0.074) | 0.033 |
| APOE4 Carrier (positive) | −0.167 (−0.328,−0.005) | −0.052* | −0.172 (−0.334,−0.011) | −0.053* | −0.304 (−0.516,−0.092) | −0.073** | −0.312 (−0.525,−0.100) | −0.075** |
| mCES-D | −0.007 (−0.012, −0.002) | −0.073* | −0.007 (−0.012, −0.002) | −0.073* | −0.006 (−0.013, 0.001) | −0.047 | −0.006 (−0.013, 0.001) | −0.049 |
| Midlife Obesity (BMI <35) | 0.015 (0.003, 0.027) | 0.064 * | 0.018 (0.005, 0.030) | 0.078 ** | 0.010 (−0.006, 0.025) | 0.033 | 0.014 (−0.003, 0.030) | 0.046 |
| Surgical Menopause | 0.008 (−0.204, 0.220) | 0.002 | 0.025 (−0.187,0.237) | 0.006 | 0.075 (−0.203, 0.354) | 0.014 | 0.085 (−0.193, 0.363) | 0.016 |
| MHT Type | ||||||||
| Unopposed Estrogen | 0.195 (0.010, 0.380) | 0.062 * | 0.176 (−0.009, 0.361) | 0.056 | 0.137 (−0.105, 0.380) | 0.034 | 0.120 (−0.123, 0.363) | 0.030 |
| Opposed Estrogen | −0.015 (−0.184, 0.155) | −0.005 | −0.045 (−0.214, 0.125) | −0.015 | −0.101 (−0.323, 0.122) | −0.027 | −0.132 (−0.355, 0.091) | −0.035 |
| Diabetes | −0.401 (−0.626, −0.175) | −0.095** | −0.519 (−0.815,−0.223) | −0.096** | ||||
| Hyperlipidemia | 0.074 (−0.072, 0.220) | 0.026 | 0.074 (−0.117, 0.266) | 0.021 | ||||
| Hypertension | −0.068 (−0.218, 0.083) | −0.024 | 0.070 (−0.128, 0.268) | 0.019 | ||||
| Heart Disease | 0.091 (−0.099, 0.281) | 0.025 | 0.157 (−0.093, 0.407) | 0.033 | ||||
| Lifetime Smoking Years | 0.001 (−0.004, 0.005) | 0.008 | 0.000 (−0.007, 0.006) | −0.004 | ||||
***
p < 0.001;
**
p < 0.01;
*
p < 0.05;
mCES-D, modified Center for Epidemiological Studies Depression Inventory Score; MHT, menopausal hormone therapy; BMI, body mass index.