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. 2023 Sep 1;26(10):107813. doi: 10.1016/j.isci.2023.107813

Figure 5.

Figure 5

EN-RAGE signature genes are induced by in vitro treatment of monocytes with IL-6. Monocytes stimulated with IL-6 for 24 h compared with media, selected genes visualized as a heatmap using unsupervised clustering

(A) EN-RAGE signature genes.

(B) Genes associated with potential T cell suppressive functionality, from Table S3.

(C) FGSEA analysis of EN-RAGE and MS1 signatures in IL-6-treated monocytes. Bars represent the normalized enrichment scores of how much each gene set is regulated by IL-6 treatment (BH adjusted p value for MS1 < 0.01 and EN-RAGE <0.001).