Table 1.

Search strategy for retrieving studies in PubMed (this will be adapted to the other databases)

Search	Query
#1	Search: (((((((((((((safety) OR (“side effects”)) OR (“adverse effects”)) OR (“adverse drug effects”)) OR (“adverse drug reactions”)) OR (“adverse events”)) OR (toxicity)) OR (tolerance)) OR (“immune tolerance”)) OR (tolerability)) OR (“Adverse events following immunization”)) OR (AEFI)) OR (“Adverse events of special interest”)) OR (AESI)
#2	Search: ((((((((RTSS) OR (RTS,S)) OR (RTS,S/AS01)) OR (RTSS/AS01)) OR (“Malaria vaccine”)) OR (Mosquirix)) OR (MVIP)) OR (MVPE)) OR (Immunization)
#3	Search: ((((((((((((((children) OR (infant)) OR (infants)) OR (toddler)) OR (toddlers)) OR (kid)) OR (kids)) OR (juvenile)) OR (“children below 5 years”)) OR (minor)) OR (minors)) OR (“young children”)) OR (“under 5 years”)) OR (“under 5”)) OR (“children 0–59 months”)
#4	Search: (#1) AND (#2) AND (#3)
#5	Search: ((((((((((((((((((((((((((((((((((((((((((((((((((“sub-Saharan Africa”) OR (Africa)) OR (SSA)) OR (Angola)) OR (Benin)) OR (Botswana)) OR (“Burkina Faso”)) OR (Burundi)) OR (Cameroon)) OR (“Cape Verde”)) OR (“Central African Republic”)) OR (Chad)) OR (Comoros)) OR (Congo)) OR (“Cote d'Ivoire”)) OR (Djibouti)) OR (“Equatorial Guinea”)) OR (Ethiopia)) OR (Eswatini)) OR (Gabon)) OR (“The Gambia”)) OR (Ghana)) OR (Guinea)) OR (“Guinea-Bissau”)) OR (Kenya)) OR (Lesotho)) OR (Liberia)) OR (Madagascar)) OR (Malawi)) OR (Mali)) OR (Mauritania)) OR (Mauritius)) OR (Mozambique)) OR (Namibia)) OR (Niger)) OR (Nigeria)) OR (Rwanda)) OR (“Sao Tome and Principe”)) OR (Senegal)) OR (Seychelles)) OR (“Sierra Leone”)) OR (Somalia)) OR (“South Africa”)) OR (Sudan)) OR (Swaziland)) OR (Tanzania)) OR (Togo)) OR (Uganda)) OR (Zaire)) OR (Zambia)) OR (Zimbabwe)
#6	Search: (#4) AND (#5)