Skip to main content
. Author manuscript; available in PMC: 2023 Oct 5.
Published in final edited form as: Cancer Cell. 2021 Dec 13;39(12):1553–1557. doi: 10.1016/j.ccell.2021.11.005

Figure 1. Discovery of optimal antigens for precision therapies via single-cell genomics.

Figure 1.

Shown is a schematic of potential antigen targets that may be identified via large-scale, single-cell atlases and prioritized via on-tumor attributes. The intersection of large-scale single-cell genomics datasets may be used to identify optimal cancer-specific antigen targets and de-prioritize non-specific targets found on indispensable cell types. For optimal targets nominated via single-cell atlases, several antibody-based therapies may be utilized (right), including antibody-drug conjugates, bispecific antibodies, or cell-based therapies.