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. 2023 Sep 22;28(5):211. doi: 10.3892/mmr.2023.13098

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — KA enhances NRF2 nuclear translocation. Macrophages were divided into three groups. CTRL group; LPS group, macrophages were treated with 200 ng/ml LPS for 24 h, and the KA/LPS group, macrophages were treated with 100 µM KA for 0.5 h followed by 200 ng/ml LPS for 24 h. (A and B) Macrophage nuclear and cytoplasmic proteins were extracted and western blotting was used to evaluate the levels of NRF2. (C and D) Immunofluorescence was used to observe the levels of NRF2 in the nuclei of different groups. (E and F) The levels of HO-1 in macrophages. **P<0.01, ***P<0.001 vs. CTRL group. ^##P<0.01, ^###P<0.001 vs. LPS. n=3 per group. KA, Kynurenic acid; LPS, lipopolysaccharide; NRF2, Nuclear factor erythroid 2-related factor 2; HO-1, Heme-oxygenase-1.