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. 2023 Sep 22;28(5):212. doi: 10.3892/mmr.2023.13099

Figure 1.

Figure 1.

The Structure of FLOT1 and FLOT2: The C-terminus of FLOT1 and FLOT2 are longer than other SPFH proteins, includes a flotillin domain, and the N-terminus also has a highly conserved PHB domain. The PHB domain of FLOT1 spans amino acids 1–154 and the flotillin domain encompasses amino acids 190–363. FLOT1 and FLOT2 interact with each other to form heterodimeric and/or oligomeric complexes. In addition, FLOT1 requires the presence of FLOT2 to be stable at the protein level. FLOT1 can be sumolylated by UBC9 at Lys15 and Lys195, and phosphorylated by PKC at Ser315 and by Fyn in Tyr160. FLOT, flotillin protein; PHB, prohibition homology; PKC, protein kinase C; IGF-1R, insulin-like growth factor-1 receptor; DAT, dopamine transporter; EAAT2, glial glutamate transporter.