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. 2023 Sep 20;8(39):36401–36411. doi: 10.1021/acsomega.3c05293

Table 4. Cytotoxicity of 1a–ta,b.

test compound DU145 HepG2 B16 CHO–K1
1a 5.24 ± 0.67 4.62 ± 0.03 9.88 ± 1.19 29.32 ± 0.40
1b 15.04 ± 1.02 7.18 ± 1.89 13.39 ± 1.01 31.39 ± 0.05
1c 2.02 ± 0.74 5.47 ± 0.56 36.03 ± 1.09 16.24 ± 0.93
1d 5.10 ± 0.26 4.93 ± 1.04 5.31 ± 0.07 18.63 ± 0.48
1e 11.99 ± 0.46 8.27 ± 1.03 8.89 ± 0.26 16.82 ± 0.66
1f 5.58 ± 0.17 4.23 ± 1.09 4.40 ± 0.35 6.13 ± 1.19
1g 8.13 ± 0.77 6.33 ± 1.8 9.82 ± 0.52 46.55 ± 0.59
1h 16.79 ± 0.65 6.23 ± 1.6 8.17 ± 0.37 11.60 ± 1.27
1i 10.28 ± 0.87 7.43 ± 1.6 15.93 ± 0.25 13.53 ± 0.73
1j 9.46 ± 1.23 5.24 ± 0.1 9.90 ± 1.61 6.38 ± 0.55
1k 1.09 ± 0.92 5.28 ± 0.24 29.24 ± 2.38 26.8 ± 1.29
1l 91.35 ± 0.81 9.73 ± 1.4 23.30 ± 0.65 24.23 ± 0.68
1m 8.18 ± 0.74 7.54 ± 1.19 9.49 ± 1.97 16.5 ± 0.88
1n 6.87 ± 1.06 11.9 ± 0.10 13.6 ± 0.92 12.36 ± 1.38
1o 60.81 ± 1.24 5.87 ± 0.30 16.14 ± 0.79 10.12 ± 0.75
1p 19.36 ± 0.88 11.39 ± 1.37 19.65 ± 0.87 30.49 ± 1.73
1q 39.52 ± 1.02 5.00 ± 0.01 23.5 ± 7.0 9.18 ± 1.58
1r 21.23 ± 2.01 5.82 ± 0.5 15.68 ± 2.10 30.46 ± 0.33
1s 22.62 ± 0.98 7.01 ± 0.53 7.02 ± 0.32 15.84 ± 0.52
1t 12.21 ± 0.96 8.12 ± 0.87 8.14 ± 1.45 15.21 ± 0.35
standard (doxorubicin) 0.7 ± 0.13 0.6 ± 0.12 0.8 ± 0.12  
standard (Mitomycin C)       13.3 ± 0.68
a

IC50 values (μM) (mean ± S.D.).

b

DU 145 -Prostate cancer cell lines; HepG2-Liver hepato cellular carcinoma cells; B16 -Melanoma cancer cell lines; CHO–K1-Chinese hamster ovary cells (normal).