Table 5.
Comparison of the genotypic distribution of the P. falciparum-malaria and control group (CG)
| Genotype | Pfa (%) | CGb (%) | P-valuec | OR (95% CI)d | OR (95% CI)e |
|---|---|---|---|---|---|
| FAS (rs10562972) | |||||
| DEL/DEL | 3 (7.1) | 1 (0.9) | 0.993 | 1.000 (0.000-∞) | 1.612 (0.000-∞) |
| INS/DEL | 12 (28.6) | 24 (23.7) | |||
| INS/INS | 27 (64.3) | 76 (75.4) | 0.392 | 0.535 (0.350–1.125) | 0.780 (0.442–1.396) |
| FADD (rs4197) | |||||
| DEL/DEL | 14 (33.3) | 45 (44.6) | 0.369 | 0.745 (0.467–1.181) | 0.780 (0.453–1.333) |
| INS/DEL | 23 (54.8) | 48 (47.5) | |||
| INS/INS | 5 (11.9) | 8 (7.9) | 0.670 | 1.342 (0.847–2.139) | 1.181 (0.534–2.491) |
| CASP8 (rs3834129) | |||||
| DEL/DEL | 5 (11.9) | 19 (18.8) | 0.049 | 0.745 (0.413–1.293) | 0.446 (0.185–0.944) |
| INS/DEL | 18 (42.9) | 43 (42.6) | |||
| INS/INS | 19 (45.2) | 39 (38.6) | 0.038 | 1.343 (0.773–2.420) | 1.867 (0.736–3.725) |
| CASP8 (rs59308963) | |||||
| DEL/DEL | 11 (26.2) | 29 (28.7) | 0.516 | 0.927 (0.568–1.497) | 0.825 (0.457–1.459) |
| INS/DEL | 20 (47.6) | 53 (52.5) | |||
| INS/INS | 11 (26.2) | 19 (18.8) | 0.157 | 1.079 (0.668–1.760) | 1.520 (0.847–2.712) |
| CASP9 (rs61079693) | |||||
| DEL/DEL | 11 (26.2) | 33 (32.7) | 0.762 | 0.889 (0.550–1.424) | 0.917 (0.520–1.596) |
| INS/DEL | 19 (45.2) | 44 (43.6) | |||
| INS/INS | 12 (28.6) | 24 (23.7) | 0.077 | 1.124 (0.702–1.817) | 1.652 (0.945–2.886) |
| CASP3 (rs4647655) | |||||
| DEL/DEL | 27 (64.3) | 51 (50.5) | 0.554 | 1.425 (0.902–2.262) | 1.176 (0.686–2.022) |
| INS/DEL | 14 (33.3) | 40 (39.6) | |||
| INS/INS | 1 (2.4) | 10 (9.9) | 0.228 | 0.702 (0.442–1.108) | 0.536 (0.161–1.326) |
| BCL2 (rs11269260) | |||||
| DEL/DEL | 7 (16.6) | 19 (18.8) | 0.385 | 0.921 (0.534–1.552) | 0.734 (0.350–1.437) |
| INS/DEL | 20(47.6) | 45 (44.6) | |||
| INS/INS | 15 (35.8) | 37 (36.6) | 0.562 | 1.086 (0.644–1.872) | 0.850 (0.488–1.463) |
| TP53 (rs17880560) | |||||
| DEL/DEL | 28 (66.6) | 63 (62.4) | 0.941 | 1.122 (0.707–1.792) | 0.979 (0.569–1.692) |
| INS/DEL | 13 (31.0) | 34 (33.7) | |||
| INS/INS | 1 (2.4) | 4 (3.9) | 0.775 | 0.891 (0.558–1.414) | 0.861 (0.271–2.186) |
Pfa, Plasmodium falciparum; CGb, Control group; P-valuec obtained through logistic regression adjusted by sex and genomic ancestry (the values highlighted in bold are statistically significant); Crude Odds Ratio (OR)d; Adjusted ORe