Table 6.
Comparison of genotypic distribution of the mixed infection-malaria and control group (CG)
| Genotype | Mixed infectiona (%) | CGb (%) | P-valuec | OR (95% CI)d | OR (95% CI)e |
|---|---|---|---|---|---|
| FAS (rs10562972) | |||||
| DEL/DEL | 1 (1.8) | 1 (0.9) | 1.000 | 1.000 (0.000-∞) | 1.000 (0.000-∞) |
| INS/DEL | 14 (21.1) | 24 (23.7) | |||
| INS/INS | 43 (74.1) | 76 (75.4) | 0.746 | 0.991 (0.480–1.246) | 1.087 (0.654–1.831) |
| FADD (rs4197) | |||||
| DEL/DEL | 31 (53.5) | 45 (44.6) | 0.456 | 1.250 (0.834–1.876) | 1.189 (0.753–1.878) |
| INS/DEL | 22 (37.9) | 48 (47.5) | |||
| INS/INS | 5 (8.6) | 8 (7.9) | 0.811 | 0.800 (0.533–1.199) | 1.084 (0.547–2.083) |
| CASP8 (rs3834129) | |||||
| DEL/DEL | 6 (10.4) | 19 (18.8) | 0.026 | 0.686 (0.401–1.139) | 0.545 (0.281–0.996) |
| INS/DEL | 34 (58.6) | 43 (42.6) | |||
| INS/INS | 18 (31.0) | 39 (38.6) | 0.201 | 1.458 (0.878–2.492) | 1.732 (0.451–2.178) |
| CASP8 (rs59308963) | |||||
| DEL/DEL | 20 (34.5) | 29 (28.7) | 0.927 | 1.176 (0.772–1.792) | 1.022 (0.631–1.644) |
| INS/DEL | 26 (44.8) | 53 (52.5) | |||
| INS/INS | 12 (20.7) | 19 (18.8) | 0.866 | 0.850 (0.558–1.296) | 1.046 (0.608–1.775) |
| CASP9 (rs61079693) | |||||
| DEL/DEL | 13 (22.4) | 33 (32.7) | 0.176 | 0.734 (0.471–1.134) | 0.709 (0.428–1.157) |
| INS/DEL | 33 (56.9) | 44 (43.6) | |||
| INS/INS | 12 (20.7) | 24 (23.7) | 0.794 | 1.362 (0.882–2.124) | 0.933 (0.554–1.554) |
| CASP3 (rs4647655) | |||||
| DEL/DEL | 29 (50.0) | 51 (50.5) | 0.958 | 0.988 (0.659–1.482) | 0.987 (0.625–1.560) |
| INS/DEL | 25 (43.1) | 40 (39.6) | |||
| INS/INS | 4 (6.9) | 10 (9.9) | 0.698 | 1.012 (0.675–1.518) | 0.874 (0.430- 1.679) |
| BCL2 (rs11269260) | |||||
| DEL/DEL | 15 (25.9) | 19 (18.8) | 0.657 | 1.267 (0.808–1.984) | 1.122 (0.665- 1.875) |
| INS/DEL | 28 (48.2) | 45 (44.6) | |||
| INS/INS | 15 (25.9) | 37 (36.6) | 0.092 | 0.789 (0.504–1.238) | 0.655 (0.399- 1.062) |
| TP53 (rs17880560) | |||||
| DEL/DEL | 30 (51.7) | 63 (62.4) | 0.327 | 0.762 (0.506–1.144) | 0.795 (0.502–1.259) |
| INS/DEL | 23 (39.7) | 34 (33.7) | |||
| INS/INS | 5 (8.6) | 4 (3.9) | 0.177 | 1.313 (0.874–1.974) | 0.805 (0.805–3.184) |
Mixed infectiona, Plasmodium mixed infection malaria; CGb, Control group; P-valuec obtained through logistic regression adjusted by sex and genomic ancestry (the values highlighted in bold are statistically significant); Crude Odds Ratio (OR)d; Adjusted ORe