Table 2.
Clinical characteristics of different groups of FIB5-CRP
| Group 1 (n = 309) |
Group 2 (n = 275) |
Group 3 (n = 268) |
Group 4 (n = 301) |
P-value | |
|---|---|---|---|---|---|
| Female, n (%) | 186 (60.19) | 156 (56.73) | 156 (58.21) | 186 (61.79) | 0.623 |
| Age (years) | 64.9 ± 14.1 | 72.5 ± 12.3 | 66.1 ± 16.7 | 71.3 ± 13.4 | < 0.001 |
| SBP (mmHg) | 127.8 ± 20.0 | 132.5 ± 23.2 | 130.1 ± 23.3 | 130.1 ± 25.3 | 0.145 |
| DBP (mmHg) | 77.2 ± 14.4 | 75.2 ± 16.4 | 77.7 ± 15.4 | 74.7 ± 15.5 | 0.044 |
| Heart rate (bpm) | 81.5 ± 20.3 | 77.7 ± 20.4 | 87.6 ± 23.4 | 87.1 ± 23.1 | < 0.001 |
| BMI, n (%) | 0.647 | ||||
| < 18.5 (kg/m2) | 18(5.83) | 19(6.91) | 15(5.60) | 27(8.97) | 0.349 |
| 18.5–24.9 (kg/m2) | 145(46.93) | 134(48.73) | 134(50.00) | 153(50.83) | 0.861 |
| 25-29.9 (kg/m2) | 109(35.28) | 97(35.27) | 94(35.07) | 97(32.23) | 0.884 |
| ≥ 30 (kg/m2) | 37(11.97) | 25(9.09) | 25(9.33) | 24(7.97) | 0.470 |
| Valvular heart disease, n (%) | 57 (18.45) | 69 (25.09) | 52 (19.40) | 62 (20.60) | 0.218 |
| Atrial fibrillation, n (%) | 104 (33.66) | 145 (52.73) | 108 (40.30) | 145 (48.17) | < 0.001 |
| Dyslipidemia, n (%) | 257(83.17) | 197(71.64) | 233(86.94) | 259(86.05) | < 0.001 |
| Hypercholesterolemia, n (%) | 38(12.30) | 18(6.55) | 37(13.81) | 25(8.31) | 0.015 |
| Hypertriglyceridemia, n (%) | 89(28.80) | 32(11.64) | 48(17.91) | 40(13.29) | < 0.001 |
| hypoHDLemia, n (%) | 215(69.58) | 174(63.27) | 209(77.99) | 232(77.08) | < 0.001 |
| Hypertension, n (%) | 178 (57.61) | 162 (58.91) | 165 (61.57) | 185 (61.46) | 0.705 |
| Diabetes mellitus, n (%) | 110 (35.60) | 99 (36.00) | 128 (47.76) | 113 (37.54) | 0.010 |
| BNP (pg/mL) | 393 (160–779) | 421 (206–918) | 541 (239–1198) | 781 (332–1343) | < 0.001 |
| Hematocrit (%) | 40.1 ± 5.9 | 37.6 ± 6.5 | 38.5 ± 6.7 | 36.0 ± 10.4 | < 0.001 |
| ALB (g/L) | 39.7 ± 3.1 | 37.9 ± 3.8 | 37.9 ± 3.7 | 35.6 ± 4.1 | < 0.001 |
| UA ((µmol/L) | 432.4 ± 142.6 | 432.8 ± 139.9 | 461.3 ± 165.2 | 464.3 ± 153.5 | 0.012 |
| Creatinine (µmol/L) | 78 (63–97) | 84 (68–107) | 82 (67–110) | 89 (68–132) | 0.001 |
| Total bilirubin (µmol/L) | 12.0 (8.8–16.7) | 13.4 (9.5–21.1) | 12.7 (9.1–18.3) | 15.0 (9.1–22.0) | 0.001 |
| Sodium (mmol/L) | 139.1 ± 3.8 | 138.8 ± 4.1 | 138.2 ± 4.4 | 137.7 ± 4.7 | < 0.001 |
| Potassium (mmol/L) | 4.0 ± 0.5 | 3.9 ± 0.6 | 3.9 ± 0.6 | 3.8 ± 0.6 | 0.036 |
| WBC (109/L) | 6.4 (5.5–7.7) | 5.3 (4.3–6.3) | 7.0 (5.6-9.0) | 6.1 (5.0–8.0) | < 0.001 |
| Prothrombin time (s) | 11.7 (10.9–12.7) | 12.3 (11.5–13.9) | 12.0 (11.3–13.1) | 12.8 (11.8–14.3) | < 0.001 |
| PLT (109/L) | 196 (168–231) | 138 (108–164) | 213 (176–254) | 144 (111–177) | < 0.001 |
| ALT (U/L) | 24.6 (16.9–38.0) | 14.2 (10.1–20.8) | 26.8 (16.8–44.0) | 16.3 (10.8–26.5) | < 0.001 |
| AST (U/L) | 22.1 (17.3–30.0) | 22.4 (17.1–31.5) | 23.2 (17.1–35.2) | 25.1 (19.0–40.0) | < 0.001 |
| Lactate dehydrogenase (U/L) | 218 (183–261) | 243 (195–335) | 236 (198–298) | 302 (231–482) | < 0.001 |
| ALP(U/L) | 66.2 (54.3–80.1) | 69.4 (55.6–86.7) | 73.7(60.3–91.6) | 80.0 (64.4-103.3) | < 0.001 |
| Total cholesterol (mg/dL) | 147.91 (122.10-183.39) | 136.89 (115.24-156.61) | 145.01 (116.01-175.56) | 129.93 (109.34-165.41) | < 0.001 |
| Triglyceride (mg/dL) | 104.96(79.72-159.88) | 85.03 (58.46-107.17) | 92.12 (73.30-131.31) | 87.25 (62.67-112.49) | < 0.001 |
| HDL-C (mg/dL) | 38.67(32.10-47.56) | 39.83(34.03–51.43) | 35.58 (28.62–42.54) | 36.74 (29.00-44.08) | < 0.001 |
| LDL-C (mg/dL) | 84.88 (63.13-108.66) | 74.63 (54.52–93.19) | 80.82(61.10-116.01) | 71.93 (51.82-100.35) | < 0.001 |
| HbA1C (%) | 6.4 ± 1.3 | 6.3 ± 1.2 | 6.8 ± 1.6 | 6.5 ± 1.5 | 0.001 |
| FPG (mmol/L) | 5.6 ± 1.9 | 5.4 ± 1.7 | 6.3 ± 2.6 | 5.9 ± 2.3 | < 0.001 |
| Hemoglobin (g/L) | 133.4 ± 20.8 | 125.2 ± 23.7 | 127.9 ± 23.7 | 117.6 ± 27.0 | < 0.001 |
| BUN (mmol/L) | 7.0 (5.8–8.8) | 7.7 (5.8–10.0) | 7.2 (5.5–10.2) | 8.1 (6.0–13.0) | < 0.001 |
| IVSTD (cm) | 0.9 (0.8-1.0) | 0.9 (0.8-1.0) | 0.9 (0.8-1.0) | 0.9 (0.8-1.0) | 0.325 |
| LVPWT (cm) | 0.9 (0.8-1.0) | 0.9 (0.8-1.0) | 0.9 (0.8-1.0) | 0.9 (0.8-1.0) | 0.474 |
| LVDd (cm) | 6.1 (5.4–6.8) | 5.8 (5.0-6.5) | 6.0 (5.3–6.7) | 5.6 (5.0-6.2) | < 0.001 |
| AoD (cm) | 3.2 (3.0-3.4) | 3.3 (3.1–3.5) | 3.2 (3.0-3.4) | 3.3 (3.0-3.5) | 0.043 |
| LAD (cm) | 4.8 (4.4–5.2) | 5.0 (4.5–5.5) | 4.8 (4.4–5.2) | 4.8 (4.3–5.2) | < 0.001 |
| LVEF (%) | 38 (29–52) | 43 (33–54) | 38 (29–52) | 44 (35–54) | < 0.001 |
| Medications at admission, n (%) | |||||
| Statins | 198 (64.08) | 145 (52.73) | 141 (52.61) | 159 (52.82) | 0.008 |
| Antiplatelet agent | 167 (54.05) | 122 (44.36) | 127 (47.39) | 130 (43.19) | 0.035 |
| Aldosterone antagonist | 133 (43.04) | 111 (40.36) | 124 (46.27) | 146 (48.50) | 0.216 |
| Beta-blocker | 237 (76.70) | 198 (72.00) | 217 (80.97) | 232 (77.08) | 0.105 |
| Diuretics | 265 (85.76) | 245 (89.09) | 230 (85.82) | 268 (89.04) | 0.422 |
| ACEI/ARB/ARNI | 143 (46.28) | 111 (40.36) | 116 (43.28) | 111 (37.00) | 0.118 |
| Digoxin | 41 (13.27) | 29 (10.55) | 33 (12.31) | 34 (11.33) | 0.760 |
| SGLT2i | 23 (7.44) | 19 (6.91) | 24 (8.96) | 25 (8.33) | 0.814 |
| Insulin | 34 (11.00) | 35 (12.73) | 39 (14.55) | 36 (12.00) | 0.627 |
Group1: high FIB5 + low CRP; Group2: low FIB5 + low CRP; Group3: high FIB5 + high CRP; Group4: low FIB5 + high CRP
SBP systolic blood pressure; DBP diastolic blood pressure; BMI body mass index; FIB-5 fibrosis-5; CRP C-reactive protein; ALB albumin; ALP alkaline phosphatase; ALT alanine aminotransferase; AST aspartate aminotransferase; PLT platelet; BNP B-type natriuretic peptide; UA uric acid; WBC white blood cell; IVSTD interventricular septum thickness; LVPWT left ventricular posterior wall thickness; LVDd left ventricular diastolic diameter; AoD aortic diameter; LAD left atrial diameter; LVEF left ventricular ejection fraction; HDL-C high-density lipoprotein cholesterol; LDL-C low-density lipoprotein cholesterol; HbA1c glycated hemoglobin; FPG fasting plasma glucose; BUN blood urea nitrogen; ACEI angiotensin-converting enzyme inhibitor; ARB angiotensin receptor inhibitors; ARNI angiotensin receptor neprilysin inhibitor; SGLT2i sodium-glucose cotransporter-2 inhibitor