Table 2. ANOVA Results for the Coefficient of the Cubic Model for Bioactive Compound Production.

source	sum of squares	df	mean square	F-value	p-value
model	0.4481	20	0.0224	20.63	<0.0001	significant
A-yeast extract	0.0000	1	0.0000	0.0230	0.8806
B-malt extract	0.0121	1	0.0121	11.14	0.0026
C-dextrose	0.0149	1	0.0149	13.70	0.0011
D-pH	0.0005	1	0.0005	0.4456	0.5106
E-temperature	0.0020	1	0.0020	1.82	0.1891
AB	0.0006	1	0.0006	0.5754	0.4552
AC	0.0002	1	0.0002	0.2071	0.6530
AD	0.0001	1	0.0001	0.0921	0.7641
AE	0.0016	1	0.0016	1.47	0.2362
BC	0.0029	1	0.0029	2.68	0.1139
BD	0.0007	1	0.0007	0.6223	0.4376
BE	0.0030	1	0.0030	2.78	0.1076
CD	0.0042	1	0.0042	3.89	0.0598
CE	0.0009	1	0.0009	0.8285	0.3714
DE	0.0000	1	0.0000	0.0230	0.8806
A2	0.0912	1	0.0912	84.00	<0.0001
B2	0.0854	1	0.0854	78.61	<0.0001
C2	0.0675	1	0.0675	62.10	<0.0001
D2	0.3044	1	0.3044	280.19	<0.0001
E2	0.1854	1	0.1854	170.67	<0.0001
residual	0.0272	25	0.0011
lack of fit	0.0242	20	0.0012	2.06	0.2162	not significant
pure error	0.0029	5	0.0006
cor total	0.4753	45