Table 3.
Continuous characteristics of all groups and univariate analysis.
PRP | NPR | P-value* | |||||
---|---|---|---|---|---|---|---|
Complete resected by VAB | Minimal residual disease on surgical pathology | Total | Gross residual disease | Upgrade | Total | ||
Number of patients | 29 (25%) | 18 (15.5%) | 47 (40.5%) | 64 (55.2%) | 5 (4.3%) | 69 (59.5%) | |
Final diagnosis: IC IC+ DCIS DCIS DCIS with microinvasion |
12 9 8 |
0 15 2 1 |
12 (25.5%) 24 (51.1%) 10 (21.3%) 1 (2.1%) |
6 24 28 6 |
0 4 0 1 |
6 (8.7%) 28 (40.6%) 28 (40.6%) 7 (10.1%) |
< 0.001 |
Age Mean ± SD (range) |
59.31 ± 12.99 (31–91) | 59.22 ± 13.39 (33–79) | 59.27 ± 12.9 (31–91) | 52.80 ± 11.32 (20–76) | 58.40 ± 8.79 (44–66) | 53.20 ± 11.19 (20–76) | 0.008 |
Tumor size on image (mm), Mean ± SD (range) | 8.03 ± 4.02 (4–25) | 9.28 ± 3.29 (5–18) | 8.50 ± 3.77 (4–25) | 15.49 ± 14.47 (4–88) | 9.33 ± 4.04 (7–14) | 15.00 ± 14.00 (4–88) | 0.008 |
Final tumor invasive size** (mm) Mean ± SD (range) |
4.99 ± 2.17 (2–11) | 5.31 ± 2.04 (1–8) | 5.11 ± 2.10 (1–11) | 12.10 ± 9.93 (1–25) | 4.76 ± 4.48 (0.8–12) | 10.66 ± 7.10 (0.80–25) | <0.001 |
Final tumor in situ size** (mm) Mean ± SD (range) |
3.88 ± 1.25 (2–6) | 2.25 ± 0.35 (2–2.5) | 3.55 ± 1.30 (2–6) | 15.96 ± 11.98 (5–65) | 15.96 ± 11.98 (5–65) | <0.001 | |
Ki67 (%) | 13.50 ± 14.99 (2–80) | 21.56 ± 21.17 (3–80) | 16.65 ± 17.88 (2–80) | 25.80 ± 19.29 (2–90) | 18.00 ± 21.68 (5–55) | 25.46 ± 19.21 (2–90) | 0.016 |
*t-test.
**Final tumor size is referred as the largest pathological tumor size measured either on the VAB/EVAB or the surgical specimen, following the TNM stage system (17).