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. 2023 Sep 21;14:1228853. doi: 10.3389/fendo.2023.1228853

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Copyright © 2023 Butler, Ramanjaneya, Moin, Hunt and Atkin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Outline of the study examining the effect of gastric bypass surgery on plasma hepatokines, adipokines, and myokines. The study subjects were subjects with diabetes who underwent bariatric surgery (n=50) compared to subjects with diabetes who were obese and did not have surgery (n=76), both having blood withdrawn 12 years after the baseline exam. Blood from the baseline exam was not analyzed. Surgical subjects were also compared to a normal-weight cohort (n=39). Frozen stored blood samples were used to measure plasma hepatokines [FGF21, angiopoietin like 3 (ANGPTL3), angiopoietin like 4 (ANGPTL4) and angiopoietin like 6 (ANGPTL6)]; adipokines (adiponectin, adipsin, measured by Luminex immune assay; and the myokine,myonectin, measured by ELISA.