Figure 4.

Weight over 192 weeks for 55 randomized HIV-1 patients receiving DTG monotherapy (n = 35) or cART (n = 20). Patients switching from cART to DTG monotherapy after week 96 were included in the switcher group (n = 9) and had their timepoint reset to 0. Patients receiving DTG prior to randomization were excluded from this analysis. Shown are trajectories/P values stratified by study group and P values for differences in the trajectories between study groups, with DTG as the reference. P values are calculated with a linear mixed model, using a random intercept model with unique patients, to assess the overall time trend. The “n patient measurements” represent patients with useable measurements at the respective time. Abbreviations: cART, combination antiretroviral therapy; DTG, dolutegravir; HIV-1, human immunodeficiency virus type 1.