Table 2.

Factors associated with overall survival (OS) after SRS treatment-1, Cox proportional hazards analysis.

Factor		Univariable				Multivariable
		HR	95 % CI lower	95 % CI upper	p-value	HR	95 % CI lower	95 % CI upper	p-value
Sex	Male	Reference				Reference
	Female	0.937	0.553	1.587	0.808	0.868	0.504	1.493	0.608
Driver oncogene	EGFR	Reference				Reference
	ALK	0.571	0.333	0.981	0.042	0.922	0.483	1.760	0.806
Age	Continuous	1.015	0.993	1.037	0.177	1.010	0.985	1.035	0.434
Brain mets at stage IV presentation	No	Reference				Reference
	Yes	1.062	0.636	1.773	0.819	0.952	0.534	1.697	0.867
No. of brain mets treated with SRS treatment-1	Continuous	1.023	0.952	1.099	0.532	1.021	0.941	1.107	0.617
WBRT prior to SRS	No	Reference				Reference
	Yes	1.052	0.557	1.988	0.876	1.281	0.610	2.689	0.512
Receipt of next-generation TKI	No	Reference				Reference
	Yes	0.375	0.213	0.659	<0.001	0.399	0.211	0.752	0.005