Table 4.

Psoriasis effectors that best classify the patients in each cluster.

Gene name	UniProt code	Mean normalized predicted protein activity value			BACC
		C1	C2	C3	C1 vs C2	C1 vs C3	C2 vs C3
ITGB1	P05556	-0.15	0.19	-0.07	0.964	0.662	0.841
ITGAE	P38570	-0.12	0.09	0.01	0.966	0.780	0.702
ITGA1	P56199	-0.18	0.24	-0.09	0.968	0.635	0.845
KDR	P35968	-0.06	0.07	-0.02	0.928	0.685	0.764
S100A9	P06702	-0.17	0.04	0.11	0.923	0.913	0.653
ITGB7	P26010	-0.17	0.24	-0.11	0.974	0.623	0.877
ERAP1	Q9NZ08	0.06	0.05	-0.11	0.510	0.958	0.959
IL4	P05112	-0.10	-0.01	0.11	0.667	0.885	0.809
DEFB4A	O15263	0.08	0.09	-0.18	0.526	0.902	0.919
FLT4	P35916	-0.01	0.01	-0.01	0.897	0.587	0.840
CXCL8	P10145	-0.19	0.03	0.14	0.811	0.868	0.645
FLT1	P17948	-0.03	0.04	-0.01	0.890	0.620	0.798
IL18	Q14116	0.02	0.08	-0.10	0.599	0.834	0.869
CCL20	P78556	0.04	0.06	-0.10	0.543	0.854	0.892
ICAM1	P05362	-0.13	-0.05	0.17	0.633	0.838	0.799
PPARD	Q03181	-0.03	-0.03	0.07	0.561	0.823	0.832
IFNA2	P01563	-0.01	-0.01	0.03	0.526	0.844	0.837
DEFB103A	P81534	-0.02	-0.02	0.04	0.523	0.837	0.823
THBS1	P07996	0.02	0.02	-0.05	0.520	0.810	0.829
EFNA1	P20827	-0.02	-0.03	0.06	0.507	0.819	0.819

Only proteins showing a BACC> 0.8 (highlighted in bold font, cross-validated p< 0.001) to classify between, at least, two of the clusters are included. The mean normalized predicted protein activity value for each cluster is provided, and values with a difference of more than 0.1 in absolute value with respect to the population mean are highlighted. Values above the mean of the remaining solutions are shaded in green and those below in red.

BACC, Cross-validated balanced accuracy; C1, C2, and C3: Cluster 1, Cluster 2, and Cluster 3.