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Schematic diagram illustrating that O-GlcNAcylation affects the malignancy of endometrial cancer by regulating the activity and phosphorylation of YAP. YAP, Yes-associated protein; OGT, O-GlcNAc transferase; ANKRD1, ankyrin repeat domain 1; CTGF, connective tissue growth factor; CYR61, cysteine-rich angiogenic inducer 61; HBP, hexosamine-biosynthesis pathway; Glc, glucose; TEAD, TEA domain transcription factor; ON, downstream pathway activation.
