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. 2023 May 30;63(1):81. doi: 10.3892/ijo.2023.5529

Figure 1.

Figure 1

LINC02038 is downregulated in CRC. (A) Heatmap of lncRNAs. lncRNAs with an FC ≥5 and P<0.05 were considered down- or upregulated. Downregulation is represented by a blue scale, while upregulation is represented by a red scale. (B) lncRNA volcano diagram of CRC vs. non-tumorous tissues. Upregulated genes are indicated in red and downregulated genes are indicated in green (defined by FC ≥1 and P<0.05). Genes in black were differentially expressed by FC <1. (C) Expression of LINC02038 based on pan-cancer analysis utilizing the TCGA and GTEx databases. LINC02038 expression was lower in COAD tissues than in normal colorectal tissues. (D and E) The expression of LINC02038 in CRC and normal colorectal tissues based on data obtained from GTEx and TCGA datasets. (F) The relationship between the LINC02038 and OS in the obtained datasets. (G) Bubble plots showing the top 21 dysregulated KEGG pathways in terms of genes associated with LINC02038 in CRC. *P<0.05, ***P<0.001. CRC, colorectal cancer; lncRNA, long non-coding RNA; TCGA, The Cancer Genome Atlas; GTEx, Genotype-Tissue Expression project; KEGG, Kyoto Encyclopedia of Genes and Genomes; COAD, colon adenocarcinoma; OS, overall survival; ns, no significance.