Table 3.
Immune response after bOPV vaccination, by participant characteristics.
| Type 1 Poliovirus (N = 320) |
Type 3 Poliovirus (N = 445) |
|||||
|---|---|---|---|---|---|---|
| Total n | % Responding (95% CI)a | p-Valueb | Total n | % Responding (95% CI) | p-Valueb | |
| Age | <0.001 | <0.001 | ||||
| 6 weeks to 3 months | 158 | 73 (66, 80) | 180 | 53 (46, 60) | ||
| 3–6 months | 115 | 56 (46, 64) | 176 | 41 (34, 48) | ||
| 6–12 months | 47 | 36 (24, 50) | 89 | 27 (19, 37) | ||
| Sex | 0.816 | 0.771 | ||||
| Male | 187 | 61 (54, 68) | 261 | 42 (37, 49) | ||
| Female | 133 | 62 (54, 70) | 184 | 44 (37, 51) | ||
| Mother’s education | 0.568 | 0.847 | ||||
| Less than primary school | 168 | 59 (51, 67) | 236 | 42 (36, 48) | ||
| Completed primary or some secondary | 58 | 66 (53, 76) | 80 | 45 (35, 56) | ||
| Completed secondary or higher | 93 | 64 (54, 73) | 128 | 44 (36, 53) | ||
| Facility | 0.010 | <0.001 | ||||
| BPKIHS | 83 | 64 (53, 73) | 116 | 50 (41, 59) | ||
| Kanti | 56 | 79 (66, 87) | 80 | 62 (52, 72) | ||
| Kosi Zonal | 63 | 56 (43, 67) | 90 | 34 (25, 45) | ||
| Nepalganj Medical College | 75 | 49 (38, 60) | 106 | 28 (21, 38) | ||
| Western Regional | 43 | 65 (50, 78) | 53 | 43 (31, 57) | ||
| Prior OPV doses | <0.001 | 0.007 | ||||
| 0 | 122 | 75 (66, 81) | 137 | 49 (41, 57) | ||
| 1 | 112 | 59 (50, 69) | 156 | 48 (40, 56) | ||
| 2 | 86 | 46 (36, 57) | 152 | 33 (26, 41) | ||
| Breastfeeding | 0.672 | 0.536 | ||||
| Exclusive | 265 | 62 (56, 68) | 361 | 44 (39, 50) | ||
| Some | 51 | 57 (43, 70) | 80 | 38 (28, 48) | ||
| None or don’t know | 4 | 75 (30, 99) | 4 | 50 (15, 85) | ||
| Stunting | 0.567 | 0.757 | ||||
| Severe | 32 | 56 (39, 72) | 47 | 40 (28, 55) | ||
| Moderate, mild or normal | 288 | 62 (56, 68) | 398 | 44 (39, 48) | ||
| Wasting | 0.381 | 0.885 | ||||
| Severe | 38 | 68 (52, 81) | 55 | 42 (30, 55) | ||
| Moderate, mild or normal | 282 | 61 (55, 66) | 390 | 43 (38, 48) | ||
| Lifetime number prior episodes of diarrhea | 0.700 | 1.000 | ||||
| 0–2 | 289 | 62 (56, 67) | 400 | 43 (38, 48) | ||
| 3+ | 31 | 58 (41, 74) | 45 | 42 (29, 57) | ||
a
Wilson score confidence interval.
b
Two-tailed Fisher’s exact test.