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The rostral anterior cingulate cortex (rACC) is an important structure in emotion regulation neurocircuitry. Several studies have shown that decreased GABA concentration in rACC is associated with neuropsychiatric symptoms such as anxiety and depression. ETI drug therapy may affect GABA function via chloride. Furthermore, rACC is dense with serotonin 2A receptors (5HT-2Ar), which are also involved in emotion regulation and directly modulated by ETI.
