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. 2023 Sep 21;10:1260883. doi: 10.3389/fmolb.2023.1260883

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Copyright © 2023 Li, Zhong, Li, Qiao, Mao, Fan, Zhong, Imani, Zheng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Basic principles of CRISPR-mediated nucleic acid detection. This figure was drawn by Figdraw. (A) RNA-guided target recognition system, which specifically recognizes and cleavages the target sequence containing PAM sites for detection by RNA-guided effector proteins. (B) Incidental cleavage system triggered by targeted recognition, after specifically recognizing and cleaving the target sequence, incidental cleavage of the surrounding labeled single-stranded nucleic acid is performed to generate detection signals for detection.