TABLE 2.

PAEs for eperezolid (PNU-100592), linezolid (PNU-100766), and vancomycin activities against selected pathogens

Organism	Agent	PAE (h)a
		1× MIC	4× MIC
S. aureus R323 (methicillin resistant)	Eperezolid	0.5 ± 0.1	0.9 ± 0.2
	Linezolid	0.5 ± 0.2	0.6 ± 0.0
	Vancomycin	1.9 ± 0.0	2.9 ± 0.0
S. epidermidis R264 (methicillin susceptible)	Eperezolid	0.2 ± 0.3	0.9 ± 0.2
	Linezolid	0.3 ± 0.5	1.1 ± 0.9
	Vancomycin	0.0 ± 0.0	2.3 ± 0.2
E. faecalis R581 (vancomycin resistant)	Eperezolid	0.1 ± 0.0	0.2 ± 0.0
	Linezolid	<0.1 ± 0.4	0.1 ± 0.0
	Vancomycin	NDb	ND
E. faecium R20 (vancomycin resistant)	Eperezolid	0.7 ± 0.4	1.2 ± 0.6
	Linezolid	0.8 ± 0.5	1.4 ± 0.3
	Vancomycin	ND	ND

^aResults are means ± standard deviations for two PAE experiments. 

^bND, not done.