Table 3.

The model family developed to reproduce the observed tumor growth measurements under treatment with doxorubicin and trastuzumab. The variables ${\varphi }_t(t)$, ${\psi }_d(t)$, and ${\psi }_t(t)$, and the parameters $r,{\tau }_d,{\tau }_t$, and ${\mathrm{\lambda }}_{di}$ are present in every model. The four-constituent models (4C) have one extra variable, the reactive oxygen species $({\varphi }_o)$. The last column indicates the number of parameters (#P) in each model.

Model	Parameter										#P
	${\mathrm{\lambda }}_t$	${\mathrm{\lambda }}_d$	${\mathrm{\lambda }}_{td}$	$K$	${\mathrm{\lambda }}_o$	${\mathrm{\lambda }}_{to}$	${\tau }_o$	${\mathrm{\lambda }}_{od}$	${\mathrm{\lambda }}_{ot}$	${\mathrm{\lambda }}_{odt}$
3CEM0	✓		✓								6
3CLM0	✓		✓	✓							7
3CEM	✓	✓	✓								7
3CLM	✓	✓	✓	✓							8
4CEM1	✓					✓	✓	✓			8
4CEM2	✓				✓		✓			✓	8
4CEM3					✓		✓		✓	✓	8
4CLM1	✓			✓		✓	✓	✓			9
4CLM2	✓			✓	✓		✓			✓	9
4CLM3				✓	✓		✓		✓	✓	9