Fig. 5.

Cell-specific differential expression of BTBD16 in brain organ. The single-cell differential expression of BTBD16 highlights the oligodendrocytes cell type with normalized RNA expression with 10.9 normalized protein-coding transcripts per million (nTPM), which is more than 10 folds higher than the other cell types. The single-cell differential expression profile of BTBD16 supports our findings in the statistical causal pathway. That is, the SNP rs6585827 variant upregulates the expression of the BTBD16 gene in oligodendrocytes, specialized glial cells, in the brain cortex, and affects the diagnosis of AD/CN by affecting the regional brain volumetric variations. Data were downloaded from the human protein atlas (Uhlén et al., 2015; Sjöstedt et al., 2020; Karlsson et al., al.). The expression level is quantified by nTPM.