FIG 5.
Forest plot of the multivariable analysis in patients with mutated TP53. (A) Forest plot of subgroup analyses in patients with mutated TP53 showing the HR for death and 95% CI in the multivariable time-dependent analysis where HCT was considered as a time-dependent variable. Multivariable Cox regression analysis was used, with adjustment for HCT, TP53 allelic state, DDX41 mutation, KMT2APTD, complex karyotype, duration of disease, IPSS score, sex, age, and performance score. (B) OS in patients with TP53 mutations in which HCT is considered as a time-dependent covariate according to a Simon-Makuch plot. Time is measured from consent and patients switch from the no HCT to the HCT at the time of HCT if they received HCT. (C) Serial analysis of enrollment and pre-HCT TP53 samples (n = 35). Patients with pre-HCT TP53 VAF ≥5% (left) and pre-HCT TP53 VAF <5% (right) are shown. (D) OS in patients with TP53 mutations by pre-HCT TP53 VAF cutoff of 5%. Time is measured from transplantation. ECOG, Eastern Cooperative Oncology Group; HCT, hematopoietic cell transplantation; HR, hazard ratio; IPSS, International Prognostic Scoring System; MDS, myelodysplastic syndrome; OS, overall survival; VAF, variant allele fraction.