Table 4.

Multivariate logistic regression analysis of the training cohort.

Variable	All-cause early death			Cancer-specific early death
	OR	95% CI	P value	OR	95% CI	P value
Age
<40	1 (ref)			NA
40–65	0.88	0.51–1.5	.636
>65	1.41	0.82–2.44	.212
Marital
Married	1 (ref)			1 (ref)
Unmarried	1.48	1.16–1.88	.002	1.37	1.08–1.73	.01
Primary site
Skin, NOS	1 (ref)			1 (ref)
Skin other/unspecific parts of face	1.42	0.56–3.59	.461	1.23	0.48–3.13	.665
Skin of scalp and neck	0.47	0.23–0.97	.04	0.53	0.26–1.08	.078
Skin of trunk	1.16	0.68–1.98	.579	0.98	0.58–1.66	.938
Skin of upper limb and shoulder	1.24	0.64–2.38	.522	1.15	0.6–2.21	.667
Skin of lower limb and hip	0.6	0.31–1.18	.14	0.66	0.34–1.28	.219
Choroid	0.09	0.01–0.76	.027	0.1	0.01–0.82	.032
External ear	0.59	0.1–3.58	.567	0.67	0.12–3.83	.648
Other rare sites	0.42	0.15–1.13	.086	0.5	0.19–1.34	.168
Melanoma type
Malignant melanoma, NOS	1 (ref)			1 (ref)
Nodular melanoma	0.91	0.51–1.62	.757	0.97	0.55–1.71	.911
Superficial spreading melanoma	0.76	0.28–2.09	.594	0.67	0.24–1.88	.448
Spindle cell melanoma, NOS	0.54	0.17–1.68	.286	0.66	0.22–2.01	.468
Amelanotic melanoma	1.09	0.44–2.66	.857	1.02	0.41–2.54	.962
Other rare types	0.54	0.23–1.3	.171	0.64	0.27–1.51	.31
T stage
T0	1 (ref)			1 (ref)
T1–T2	1.08	0.53–2.22	.824	1.09	0.53–2.21	.82
T3–T4	1.46	0.78–2.71	.236	1.44	0.78–2.66	.249
TX	1.22	0.91–1.63	.19	1.16	0.87–1.55	.317
N Stage
N0	1 (ref)			1 (ref)
N1	1.29	0.91–1.82	.147	1.27	0.9–1.79	.168
N2	0.39	0.17–0.9	.027	0.4	0.18–0.91	.03
N3	1.16	0.66–2.04	.613	0.95	0.54–1.7	.874
NX	1.77	1.33–2.35	0	1.67	1.26–2.21	0
Surgery
No	1 (ref)			1 (ref)
Yes	0.42	0.27–0.66	0	0.48	0.31–0.75	.001
Chemotherapy
No	1 (ref)			1 (ref)
Yes	0.27	0.2–0.36	0	0.29	0.22–0.38	0
Bone metastasis
No	1 (ref)			1 (ref)
Yes	1.5	1.13–2	.005	1.33	1–1.77	.047
Brain metastasis
No	1 (ref)			1 (ref)
Yes	2	1.56–2.55	0	1.91	1.5–2.43	0
Liver metastasis
No	1 (ref)			1 (ref)
Yes	2.23	1.7–2.92	0	2.21	1.69–2.88	0
Lung metastasis
No	1 (ref)			1 (ref)
Yes	1.45	1.14–1.84	.003	1.46	1.15–1.86	.002