Table 2.

Five-, and 10-years OS and CSS for different subgroups.

	5-OS [95% CI]	10-OS [95% CI]	5-CSS [95% CI]	10-CSS [95% CI]
All cohort	75.7 [71.5–80.1]	70.7 [66.0–75.7]	77.4 [73.3–81.7]	73.1 [68.6–0.78]
Year at diagnosis, N (%)
2000–2004	70.1 [61.9–79.3]	68.2 [59.9–77.6]	72.2 [64.1–81.3]	71.2 [63.0–80.5]
2005–2009	75.2 [67.8–83.5]	68.3 [60.2–77.5]	75.2 [67.8–83.5]	68.3 [60.2–77.5]
2010–2014	78.7 [71.2–87.1]		80.5 [73.1–88.6]
2015–2019
Age at diagnosis
0–1 year	91.4 [86.4–96.7]	91.4 [86.4–96.7]	92.3 [87.5–97.3]	92.3 [87.5–97.3]
1–4 year	73.4 [67.0–80.4]	68.6 [61.6–76.5]	75.9 [69.6–82.7]	70.9 [63.9–78.7]
4–11 year	69.8 [59.9–82.6]	59.6 [47.4–74.9]	71.1 [60.3–83.8]	60.7 [48.5–76.1]
11–19 year	57.9 [45.7–73.2]	46.6 [33.1–65.7]	50.0 [46.7–74.4]	54.7 [40.5–72.2]
Sex
Female	79.0 [73.4–84.9]	75.4 [69.2–82.2]	80.2 [74.7–86.1]	78.5 [72.7–84.8]
Male	72.7 [66.7–79.2]	66.3 [59.5–73.8]	74.8 [68.9–81.2]	68.2 [61.4–75.7]
Race
White	75.6 [70.9–80.7]	71.1 [65.9–76.7]	77.4 [72.8–82.4]	73.9 [68.8–79.3]
Black	76.1 [65.1–89.0]	72.8 [60.9–87.1]	78.4 [67.8–90.6]	75.0 [63.3–88.8]
Other	75.7 [63.5–90.4]	55.9 [34.0–92.0]	75.7 [63.5–90.4]	55.9 [34.0–92.0]
Median household incomes
$0-$59,999	80.0 [72.8–88.0]	75.7 [67.5–84.8]	81.3 [74.2–89.1]	78.4 [70.5–87.1]
$60,000-$69,999	72.8 [65.6–80.7]	66.4 [58.2–75.7]	74.0 [66.8–81.8]	68.9 [60.9–77.9]
$70,000+	75.2 [68.5–82.5]	71.1 [63.8–79.2]	77.6 [71.1–84.7]	73.4 [66.1–81.4]
Region
Metropolitan	75.2 [70.8–79.9]	70.1 [65.2–75.5]	77.1 [72.7–81.7]	72.9 [68.0–78.0]
Nonmetropolitan	79.7 [68.0–93.3]	75.3 [62.0–91.3]	79.7 [68.0–93.3]	75.3 [62.0–91.3]
Histology
Neuroblastoma	77.4 [72.5–82.6]	73.3 [67.9–79.2]	79.4 [74.6–84.4]	75.8 [70.5–81.5]
Other	71.9 [64.3–80.3]	64.9 [56.2–74.9]	73.0 [65.5–81.4]	67.4 [58.9–77.1]
Tumor size
≤8 cm	83.6 [77.6–90.2]	81.5 [74.9–88.6]	85.4 [79.5–91.8]	84.3 [78.1–91.0]
8 + cm	72.5 [66.2–79.3]	64.5 [57.2–72.9]	73.7 [67.5–80.5]	65.6 [58.2–74.0]
Unknown	68.7 [58.9–80.3]	64.5 [53.9–77.2]	71.5 [61.8–82.7]	69.7 [59.8–81.3]
Months to treatment
0	78.8 [74.3–83.6]	73.6 [68.4–79.2]	80.5 [76.1–85.2]	76.3 [71.3–81.6]
1+	65.1 [55.9–75.9]	60.9 [50.9–72.8]	66.8 [57.6–77.5]	62.5 [52.4–74.5]
Stage
Distant	60.0 [52.9–68.1]	54.4 [46.9–63.1]	62.4 [55.2–70.5]	56.6 [48.9–65.4]
Localized	94.2 [89.4–99.3]	89.6 [82.1–97.8]	94.2 [89.4–99.3]	89.6 [82.1–97.8]
Regional	83.3 [77.3–89.6]	78.8 [71.9–86.3]	84.7 [79.0–90.8]	82.5 [76.3–89.3]
Surgical treatment
None	59.1 [49.5–70.7]	55.6 [45.6–67.7]	64.3 [54.5–75.8]	60.4 [50.1–72.7]
Local tumor excision/destruction	84.4 [76.8–92.6]	80.0 [70.9–90.1]	84.4 [76.8–92.6]	80.0 [70.9–90.1]
Simple/partial surgical removal of primary site	77.3 [68.6–87.3]	72.6 [62.5–84.3]	77.3 [68.6–87.3]	74.9 [65.3–85.8]
Total/radical surgical removal of primary site	79.3 [73.0–86.3]	73.3 [66.0–81.4]	80.6 [74.4–87.4]	75.6 [68.5–83.4]
Surgery for non-primary other distant sites
None	76.8 [72.5–81.4]	72.0 [67.1–77.3]	78.7 [74.5–83.2]	74.9 [70.1–80.0]
Yes	66.2 [53.6–81.8]	59.6 [46.1–77.0]	66.2 [53.6–81.8]	59.6 [46.1–77.0]
Lymphnodes examined
None	74.5 [68.9–80.4]	70.0 [63.8–76.7]	76.5 [71.0–82.4]	72.6 [66.5–79.2]
2 nodes	70.7 [60.3–82.9]	68.4 [57.5–81.2]	70.7 [60.3–82.9]	68.4 [57.5–81.2]
3 + node	87.2 [79.3–96.0]	81.2 [70.6–93.4]	89.0 [81.6–97.1]	86.6 [78.2–95.9]
Unknown	72.1 [59.3–87.7]	60.1 [45.2–79.9]	74.4 [61.8–89.6]	62.0 [47.0–81.9]
Radiotherapy
No	79.0 [74.6–83.8]	76.5 [71.8–81.6]	81.3 [77.0–85.9]	79.3 [74.7–84.1]
Yes	63.7 [54.2–75.0]	48.6 [37.3–63.4]	63.7 [54.2–75.0]	51.2 [40.0–65.4]
Chemotherapy
No/Unknown	97.0 [93.7–100.0]	93.0 [87.0–99.5]	97.0 [93.7–100.0]	94.9 [89.9–100.0]
Yes	68.5 [63.4–74.1]	63.2 [57.5–69.3]	70.7 [65.6–76.2]	65.7 [60.1–71.8]

CI = confidence interval, CSS = cancer-special survival, HR = hazard ratio, OS = overall survival, sHR = sub-distribution hazard ratio.