Table 2.
Incidence rates of events during follow-up per 100 person-yr of patients prescribed raltegravir and other third-line drugs for salvage regimens.
| Events during follow-up | Eligible population (n = 168; 178.05 p-y) |
Matched subset (n = 90; 98.06 p-y) |
IRR (95%CI)*; P† | ||
|---|---|---|---|---|---|
| Raltegravir (n = 123, 129.54 p-y) |
Other drugs (n = 45, 48.51 p-y) |
Raltegravir (n = 45, 49.55 p-y) |
Other drugs (n = 45, 48.51 p-y) |
||
| Drug toxicity | 0.77 | 2.06 | 0.00 | 2.06 | −, .49 |
| Treatment interruption | 12.35 | 0.00 | 8.07 | 0.00 | −, .06 |
| Virologic failure | 2.32 | 4.12 | 2.02 | 4.12 | .49 (.04–5.40), .61 |
| Loss of follow-up | 3.86 | 4.12 | 6.05 | 4.12 | 1.47 (.25–8.79), .70 |
| Death | 4.63 | 6.18 | 4.04 | 6.18 | .65 (.11–3.91), .67 |
CI = confidence interval, p-y = person-year.
IRR (incidence rate ratio) and 95% CI for rates of each event by salvage regimen were calculated by Poisson regression, where other drugs were considered as comparators.
Wald test P value.