Table 2.

List of medications with their class and side effects that are used for motor symptoms.

Main indication	Drug class	Medication’s name	Side effects
Severe motor symptoms	Levodopa derived:	Levodopa-carbidopa	Nausea and vomiting, constipation, depression, orthostatic hypotension, dyskinesia, and hallucinations
		Levodopa-benserazide
	Dopamine agonist:	Pramipexole	Nausea and vomiting, somnolence, dyskinesia, orthostatic hypotension, hallucinations, ICDs, edema, and increased sleepiness (including sleep attacks)
		Ropinirole
		Rotigotine
Mild motor symptoms or fluctuations	MAOBIs	Selegiline	Nausea and vomiting, dyskinesia, abdominal pain, dry mouth, the stimulant effect, and exacerbation of levodopa adverse effects
		Rasagiline	EPS (dyskinesia, dystonia), headache, nausea and vomiting, orthostatic hypotension, arthralgia, dyspepsia, depression, flu-like syndrome, exacerbation of levodopa adverse effects, and constipation
		Safinamide	Nausea and vomiting, dyskinesia, hypertension, increasing liver enzymes, and insomnia
Motor fluctuations	COMTIs	Entacapone	Nausea and vomiting, dyskinesia, diarrhea, dark-colored urine, and exacerbation of levodopa adverse effects
		Tolcapone	Nausea and vomiting, dyskinesia, insomnia, dark-colored urine, hallucinations, headache, exacerbation of levodopa adverse effects, and hepatotoxicity
Gait instability and dyskinesia	Antiviral	Amantadine	Hallucinations, confusion, edema at the ankle, livedo reticularis, nausea, dry mouth, blurred vision, and constipation
	Antipsychotic	Clozapine	Hypersalivation, agranulocytosis, myocarditis, constipation, seizures, sedation, fever, dizziness, and orthostatic hypotension
Tremor	β-Blocker	Propranolol	Fatigue, bradycardia, hypotension, hypoglycemia, and depression
	Anticholinergic	Trihexyphenidyl	Hallucinations, rash, CI, nausea, dry mouth, blurred vision, urinary retention, and constipation
		Benztropine