Table 3.

Treatment algorithm for Parkinson’s disease symptoms.

Patients’ main concern	Mild symptoms	Severe symptoms
Tremor	Beta-blockers	Levodopa (first line if patient older than 60 years old)152–154
	Anticholinergic drugs	Clozapine129,142,143
		Surgical intervention
Bradykinesia and slowness	MAOBis	Age <60 years: dopamine agonists±levodopa129,140,141
		Age >60 years: levodopa ±dopamine agonist, COMTi, MAOBi129,140,141 Deep brain stimulation
Postural instability and gait impairment	MAOBi144	Age <60 years: dopamine agonists±levodopa129,140,141
	Amantadine129,145,146	Age >60 years: levodopa±amantadine, cholinesterase inhibitors If symptoms are fluctuating: levodopa±dopamine agonist, COMTi, MAOBi deep brain stimulation