TABLE 4.

Reported Failure Rates for Prethalamotomy vs Post-Thalamotomy Studies Included in Either Efficacy or Adverse Outcome Analyses

Authors	Year	FUS or SRS	n	Failure definition	Failure rate
C Pae et al.28	2022	FUS	72	<50% contralateral CRST improvement at 6 mo	0.18
J Torii et al.44	2021	FUS	61	<50% contralateral CRST improvement at 3 mo	0.51
K Yamamoto et al.51	2019	FUS	6	Recurrence at 3 mo	0.33
Y Meng et al.52	2018	FUS	35	<50% tremor improvement at 1 y	0.54
FUS aggregate			174		0.37b
C Tuleasca et al.42	2017	SRS	17	≤50% improvement in TSTH	0.35
A Niranjan et al.20	2017	SRS	91	No improvement in any FTM scores	0.12
C Ohye et al.60	2012	SRS	53a	≤50% improvement in tremor	0.15a
SY Lim et al.43	2010	SRS	17	Lack of tremor suppression	0.12
D Kondziolka et al.9	2008	SRS	27	Lack of tremor improvement	0.11
C Ohye et al.61	2002	SRS	11	<75% tremor reduction	0.22
RF Young et al.22	2000	SRS	51	Criteria not described, “treatment failure”	0.079
A Niranjan et al.23	2000	SRS	8	<50% tremor improvement	0.00
RF Young et al.24	1998	SRS	27	Little or no reduction in tremor	0.11
SRS aggregate			302		0.13b

CRST, Clinical Rating Scale for Tremor; FTM, Fahn-Tolosa-Marin; FUS, focused ultrasound; SRS, stereotactic radiosurgery; TSTH, tremor score for the treated hand.

^aIncludes both essential tremor and Parkinson disease patient populations.

^bFrom studies that explicitly reported failure rates, poor responses, or nonresponder cohort.