FIG. 1.

Representative curves for control growth (•), control regrowth (○), killing (▪), and regrowth after killing (□) of P. aeruginosa and S. aureus determined during all experiments with the pharmacokinetic model. For these curves the samples for PAE measurement were taken when the tobramycin concentration was 5× the MIC during the simulation with a half-life of 1.5 h. PAE can be determined as PAE = T − C, as described by Craig and Gudmundsson (4) (see text for details).