TABLE 1.

Comparison of tobramycin PAEs for P. aeruginosa and S. aureus determined in vitro and during simulation of in vivo PAE

Strain	Half-life (h)	PAE (h)a
		20× the MIC	1× the MIC	Simulation of in vivo PAE
P. aeruginosa	1.5	2.0 ± 0.8	0.9 ± 0.3	6.1 ± 0.5
	2.0	1.7 ± 0.3	0.7 ± 0.1	5.1 ± 0.1
	2.5	2.5 ± 1.0	−0.2 ± 0.3	5.0 ± 1.5
S. aureus	1.5	1.7 ± 0.1	0.9 ± 0.2	2.3 ± 1.0
	2.0	1.3 ± 0.3	0.3 ± 0.5	4.0 ± 1.3
	2.5	2.2 ± 0.8	0.1 ± 0.2	1.3 ± 0.1

^aData are means ± SEMs for two separate experiments.